Liao Qijun, Wang Fuxiang, Zhou Wudi, Liao Guancheng, Zhang Haoyang, Shu Yuelong, Chen Yongkun
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.
BGI Genomics, Shenzhen 518085, China.
Microorganisms. 2024 Jun 8;12(6):1170. doi: 10.3390/microorganisms12061170.
Numerous studies have reported a correlation between gut microbiota and influenza A virus (IAV) infection and disease severity. However, the causal relationship between these factors remains inadequately explored. This investigation aimed to assess the influence of gut microbiota on susceptibility to human infection with H7N9 avian IAV and the severity of influenza A (H1N1)pdm09 infection. A two-sample Mendelian randomization analysis was conducted, integrating our in-house genome-wide association study (GWAS) on H7N9 susceptibility and H1N1pdm09 severity with a metagenomics GWAS dataset from a Chinese population. Twelve and fifteen gut microbiotas were causally associated with H7N9 susceptibility or H1N1pdm09 severity, separately. Notably, and were negative associated with H7N9 susceptibility and H1N1pdm09 severity, respectively. Moreover, and were associated with H7N9 susceptibility, while and were correlated with H1N1pdm09 severity. These results provide novel insights into the interplay between gut microbiota and IAV pathogenesis as well as new clues for mechanism research regarding therapeutic interventions or IAV infections. Future studies should concentrate on clarifying the regulatory mechanisms of gut microbiota and developing efficacious approaches to reduce the incidence of IAV infections, which could improve strategy for preventing and treating IAV infection worldwide.
众多研究报告了肠道微生物群与甲型流感病毒（IAV）感染及疾病严重程度之间的相关性。然而，这些因素之间的因果关系仍未得到充分探索。本研究旨在评估肠道微生物群对人类感染H7N9禽流感IAV易感性以及甲型流感（H1N1）pdm09感染严重程度的影响。我们进行了一项两样本孟德尔随机化分析，将我们内部关于H7N9易感性和H1N1pdm09严重程度的全基因组关联研究（GWAS）与来自中国人群的宏基因组GWAS数据集相结合。分别有12种和15种肠道微生物群与H7N9易感性或H1N1pdm09严重程度存在因果关联。值得注意的是，[具体微生物群1]和[具体微生物群2]分别与H7N9易感性和H1N1pdm09严重程度呈负相关。此外，[具体微生物群3]和[具体微生物群4]与H7N9易感性相关，而[具体微生物群5]和[具体微生物群6]与H1N1pdm09严重程度相关。这些结果为肠道微生物群与IAV发病机制之间的相互作用提供了新的见解，也为治疗干预或IAV感染的机制研究提供了新线索。未来的研究应集中于阐明肠道微生物群的调控机制，并开发有效的方法来降低IAV感染的发生率，这可能会改善全球预防和治疗IAV感染的策略。
