使用新型[(bpy)Cu(OCCFSOF)]试剂实现卤代烃的高效三氟甲基化反应。
Efficient Trifluoromethylation of Halogenated Hydrocarbons Using Novel [(bpy)Cu(OCCFSOF)] Reagent.
作者信息
Wu Xiong, Qiu Xin, Lou Wenrun, Zhang Shengxue, Zhang Chaoyi, Ma Xiaoyu, Liu Chao
机构信息
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China.
Shanghai-Sanming Engineering Research Center of Green Fluoropharmaceutical Technology, 25 Jingdong Road, Sanming 365004, China.
出版信息
Molecules. 2024 Jun 14;29(12):2849. doi: 10.3390/molecules29122849.
This study introduces a novel trifluoromethylating reagent, [(bpy)Cu(OCCFSOF)], notable for not only its practical synthesis from cost-effective starting materials and scalability but also its nonhygroscopic nature. The reagent demonstrates high efficiency in facilitating trifluoromethylation reactions with various halogenated hydrocarbons, yielding products in good yields and exhibiting broad functional group compatibility. The development of [(bpy)Cu(OCCFSOF)] represents an advancement in the field of organic synthesis, potentially serving as a valuable addition to the arsenal of existing trifluoromethylating agents.
本研究介绍了一种新型三氟甲基化试剂[(bpy)Cu(OCCFSOF)]，它不仅因其可由经济高效的起始原料通过实用的合成方法制备且具有可扩展性而引人注目，还因其不吸湿的特性而备受关注。该试剂在促进与各种卤代烃的三氟甲基化反应中表现出高效性，能以良好的产率生成产物，并具有广泛的官能团兼容性。[(bpy)Cu(OCCFSOF)]的开发代表了有机合成领域的一项进展，有可能成为现有三氟甲基化试剂库中的一种有价值的补充。
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