Bera Atanu, Banerjee Debasis
Department of Chemistry, Laboratory of Catalysis and Organic Synthesis, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India.
Org Biomol Chem. 2023 Dec 6;21(47):9298-9315. doi: 10.1039/d3ob01132a.
This review highlights the recent advances, from 2015 to 2023, on the introduction of organo-fluorine derivatives at the N-heteroarene core. Notable features considering new technologies based on organofluorine compounds such as: (i) approaches based on non-precious metal catalysis (Fe, Co, Mn, Ni, .), (ii) the development of new strategies using non-precious metal-catalysts for the introduction of organo-fluorinine derivatives using N-heterocycles with one or more heteroatoms, (iii) newer reagents for fluorination, difluoromethylation, trifluoromethylation, or perfluoroalkylation of N-heteroarenes using different approaches, (iv) mechanistic studies on various catalytic transformations, as and when required, and (v) the synthetic applications of various bio-active organo-fluorine compounds, including post-synthetic drug derivatization, are discussed.
本综述重点介绍了2015年至2023年期间在N-杂芳烃核心引入有机氟衍生物方面的最新进展。考虑到基于有机氟化合物的新技术的显著特点如下：(i) 基于非贵金属催化（铁、钴、锰、镍等）的方法；(ii) 开发使用非贵金属催化剂通过含一个或多个杂原子的N-杂环引入有机氟衍生物的新策略；(iii) 使用不同方法对N-杂芳烃进行氟化、二氟甲基化、三氟甲基化或全氟烷基化的新型试剂；(iv) 根据需要对各种催化转化进行机理研究；(v) 讨论了各种生物活性有机氟化合物的合成应用，包括合成后药物衍生化。
