Cabald Tressy, Marie-Magdeleine Carine, Philibert Lucien, Caradeuc Cédric, Bertho Gildas, Giraud Nicolas, Cebrián-Torrejón Gerardo, Sylvestre Muriel
COVACHIM-M2E Laboratory EA 3592, Department of Chemistry, University of the French West Indies, Fouillole Campus, UFR SEN, 97157 Pointe-à-Pitre, France.
INRAE, ASSET, 97170 Petit-Bourg, France.
Pharmaceuticals (Basel). 2024 Jun 13;17(6):774. doi: 10.3390/ph17060774.
Gastrointestinal parasitism is a major health and welfare problem in ruminants. Synthetic chemical anthelmintic drugs have led to the emergence of resistance in gastrointestinal strongyles, inducing the search for alternatives to control the infections that affect ruminants. The objective of this work was to evaluate the anthelmintic potential of plant extracts against Rudolphi. Three plants of the Guadeloupean biodiversity, L., L. and spp., were selected based on their high polyphenolic content and natural abundance. The phytochemistry of plants was explored, a biological assay against the parasite was carried out, and several hypotheses about the way of action were proposed by an innovative electrochemical screening method.
胃肠道寄生虫感染是反刍动物健康和福利的一个主要问题。合成化学驱虫药已导致胃肠道圆线虫产生抗药性,促使人们寻找控制影响反刍动物感染的替代方法。这项工作的目的是评估植物提取物对鲁道夫属寄生虫的驱虫潜力。根据瓜德罗普岛生物多样性中的三种植物(具体植物名称未给出)的高多酚含量和自然丰度进行了选择。对这些植物的植物化学性质进行了研究,针对该寄生虫进行了生物测定,并通过一种创新的电化学筛选方法提出了几种关于作用方式的假设。