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通过自缩聚反应化学合成无规聚-3-羟基丁酸酯（a-P3HB）：催化剂筛选与表征

Chemical Synthesis of Atactic Poly-3-hydroxybutyrate (a-P3HB) by Self-Polycondensation: Catalyst Screening and Characterization.

作者信息

Almustafa Wael, Schubert Dirk W, Grishchuk Sergiy, Sebastian Jörg, Grun Gregor

机构信息

Department of Applied Logistics and Polymer Sciences, Kaiserslautern University of Applied Science, Schoenstr. 11, 67659 Kaiserslautern, Germany.

Institute of Polymer Materials, Department of Materials Science, Faculty of Engineering, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Martensstr. 7, 91058 Erlangen, Germany.

出版信息

Polymers (Basel). 2024 Jun 11;16(12):1655. doi: 10.3390/polym16121655.

DOI:10.3390/polym16121655
PMID:38932005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11207747/
Abstract

Poly-3-hydroxybutyrate (P3HB) is a biodegradable polyester produced mainly by bacterial fermentation in an isotactic configuration. Its high crystallinity (about 70%) and brittle behavior have limited the process window and the application of this polymer in different sectors. Atactic poly-3-hydroxybutyrate (a-P3HB) is an amorphous polymer that can be synthesized chemically and blended with the isotactic P3HB to reduce its crystallinity and improve its processability Ring-opening polymerization (ROP) is the most cited synthesis route for this polymer in the literature. In this work, a new synthesis route of a-P3HB by self-polycondensation of racemic ethyl 3-hydroxybutyrate will be demonstrated. Different catalysts were tested regarding their effectiveness, and the reaction parameters were optimized using titanium isopropoxide as the catalyst. The resulting polymers were compared by self-polycondensation for their properties with those of a-P3HB obtained by the ROP and characterized by Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC), and the double bond content (DBC) was determined by UV-VIS spectroscopy by using 3-butenoic acid as a standard. Additionally, a life cycle analysis (LCA) of the new method of synthesizing has been carried out to assess the environmental impact of a-P3HB.

摘要

聚-3-羟基丁酸酯（P3HB）是一种主要通过细菌发酵以全同立构构型生产的可生物降解聚酯。其高结晶度（约70%）和脆性限制了该聚合物在不同领域的加工窗口和应用。无规聚-3-羟基丁酸酯（a-P3HB）是一种无定形聚合物，可以通过化学合成并与全同立构的P3HB共混以降低其结晶度并改善其加工性能。文献中最常提及的该聚合物的合成路线是开环聚合（ROP）。在这项工作中，将展示一种通过外消旋3-羟基丁酸乙酯的自缩聚合成a-P3HB的新路线。测试了不同催化剂的有效性，并以异丙醇钛为催化剂优化了反应参数。通过自缩聚将所得聚合物的性能与通过ROP获得的a-P3HB的性能进行比较，并通过傅里叶变换红外光谱（FTIR）和凝胶渗透色谱（GPC）进行表征，以3-丁烯酸为标准通过紫外可见光谱法测定双键含量（DBC）。此外，还对新的合成方法进行了生命周期分析（LCA），以评估a-P3HB的环境影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/10333ea7c50b/polymers-16-01655-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/b77011d529f6/polymers-16-01655-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/82414518ed16/polymers-16-01655-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/0163781d02d8/polymers-16-01655-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/dc9cc26e219f/polymers-16-01655-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/f2dcbc65a77b/polymers-16-01655-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/38a046dbf79f/polymers-16-01655-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/9824eccf3a1f/polymers-16-01655-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/10333ea7c50b/polymers-16-01655-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/b77011d529f6/polymers-16-01655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/b811cc12854a/polymers-16-01655-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/1ca2862de768/polymers-16-01655-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/4c0fb8f241ca/polymers-16-01655-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/73d4e4bab015/polymers-16-01655-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/f621b921189b/polymers-16-01655-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/82414518ed16/polymers-16-01655-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/0163781d02d8/polymers-16-01655-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/dc9cc26e219f/polymers-16-01655-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/f2dcbc65a77b/polymers-16-01655-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/38a046dbf79f/polymers-16-01655-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/9824eccf3a1f/polymers-16-01655-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fa/11207747/10333ea7c50b/polymers-16-01655-g013.jpg

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