National Biosafety Laboratory, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary.
School of PhD Studies, Semmelweis University, 1091 Budapest, Hungary.
Viruses. 2024 May 29;16(6):875. doi: 10.3390/v16060875.
(1) Background: Crimean-Congo hemorrhagic fever (CCHF) is an emerging tick-borne disease endemic in Africa, Asia, the Middle East, and the Balkan and Mediterranean regions of Europe. Although no human CCHF cases have been reported, based on vector presence, serological evidence among small vertebrates, and the general human population, Hungary lies within high evidence consensus for potential CCHF introduction and future human infection. Thus, the aim of our pilot serosurvey was to assess CCHF seropositivity among cattle and sheep as indicator animals for virus circulation in the country. (2) Methods: In total, 1905 serum samples taken from free-range cattle and sheep in 2017 were tested for the presence of anti-CCHF virus IgG antibodies using commercial ELISA and commercial and in-house immunofluorescent assays. (3) Results: We found a total of eleven reactive samples (0.58%) from five administrative districts of Hungary comprising 8 cattle and 3 sheep. The most affected regions were the south-central and northwestern parts of the country. (4) Conclusions: Based on these results, more extended surveillance is advised, especially in the affected areas, and there should be greater awareness among clinicians and other high-risk populations of the emerging threat of CCHF in Hungary and Central Europe.
(1) 背景：克里米亚-刚果出血热（CCHF）是一种在非洲、亚洲、中东以及欧洲的巴尔干和地中海地区流行的新兴蜱传疾病。尽管尚未报告人类 CCHF 病例，但根据媒介存在、小型脊椎动物中的血清学证据以及一般人群情况，匈牙利存在着 CCHF 传入和未来人类感染的高证据共识。因此，我们的初步血清学调查旨在评估牛和羊作为该国病毒传播指示动物的 CCHF 血清阳性率。(2) 方法：2017 年共采集了 1905 份来自自由放养牛和羊的血清样本，使用商业 ELISA 以及商业和内部免疫荧光检测试剂盒检测抗 CCHF 病毒 IgG 抗体的存在情况。(3) 结果：我们在匈牙利的五个行政区共发现了 11 个反应性样本（0.58%），来自 8 头牛和 3 只羊。受影响最严重的地区是该国的中南部和西北部。(4) 结论：基于这些结果，建议进行更广泛的监测，特别是在受影响的地区，并且临床医生和其他高危人群应该更加意识到 CCHF 在匈牙利和中欧的新兴威胁。
