Molecular Biology Laboratory-MBL, Department of Clinical Medicine, Faculty of Veterinary Medicine, University of Khartoum, P.O. Box 32, Khartoum North, Sudan.
Virol J. 2013 Jun 5;10:178. doi: 10.1186/1743-422X-10-178.
Crimean Congo hemorrhagic fever (CCHF), caused by CCHF virus (CCFV), may cause a fatal hemorrhagic illness in humans with mortality rate of approximately 30%. However, in animals the disease is typically asymptomatic and no clinical hemorrhagic infections appears to be associated with CCHFV. Recently, CCHF activity has been detected in western and southern Kordufan region, Sudan. Currently, no information is available in regard to previous exposure of livestock to CCHFV infection in the region.
In the present study, a seroepidemiological survey was conducted to determine the prevalence of CCHF and to identify the potential risk factors associated with the disease among cattle in North Kordufan State, Sudan.
In this survey, 299 blood samples were collected randomly from six localities in North Kordufan State and were tested by enzyme-linked immunosorbent assay (ELISA) for detection of CCHFV-specific immunoglobulin G (IgG) antibodies.
The result of the study indicated that the prevalence rate of CCHF was relatively high among cattle, where serological evidence of the infection was observed in 21 (7.0%) of 299 animals. Older cattle were eight times more likely to be infected with the virus (OR=8.0824, CI=1.174-66.317, p-value=0.034). Cross breeds were at 37 time higher at risk compared to endogenous breed (OR=37.06, CI=1.455-944, p-value=0.029). Highly tick-infested cattle are 6 times higher at risk for CCHF when compared to tick-free animals (OR=6.532, CI=1.042-10.852, p-value=0.030).
It is recommended that surveillance of CCHF should be extended to include other ruminant animals and to study the distribution of ticks in the region to better predict and respond to CCHF outbreak in the State of North Kordufan, Sudan.
克里米亚-刚果出血热（CCHF）由克里米亚-刚果出血热病毒（CCHFV）引起，在人类中可能导致致命性出血性疾病，死亡率约为 30%。然而，在动物中，该疾病通常无症状，且没有临床出血性感染与 CCHFV 有关。最近，苏丹西部和南部科尔多凡地区检测到了 CCHF 活动。目前，该地区以前家畜接触 CCHFV 感染的信息尚不清楚。
本研究旨在通过酶联免疫吸附试验（ELISA）对北科尔多凡州苏丹的牛进行血清流行病学调查，以确定 CCHF 的流行情况，并确定与该病相关的潜在危险因素。
在本次调查中，随机从北科尔多凡州的六个地点采集了 299 份血样，并通过 ELISA 检测 CCHFV 特异性免疫球蛋白 G（IgG）抗体，以检测 CCHFV 特异性 IgG 抗体。
研究结果表明，牛中 CCHF 的流行率相对较高，299 只动物中有 21 只（7.0%）血清学证据表明存在感染。年龄较大的牛感染病毒的可能性是八倍（OR=8.0824，CI=1.174-66.317，p 值=0.034）。杂交牛感染风险比本地品种高 37 倍（OR=37.06，CI=1.455-944，p 值=0.029）。与无蜱牛相比，高度感染蜱的牛感染 CCHF 的风险高 6 倍（OR=6.532，CI=1.042-10.852，p 值=0.030）。
建议将 CCHF 监测扩展到包括其他反刍动物，并研究该地区蜱的分布情况，以更好地预测和应对北科尔多凡州的 CCHF 疫情。
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