Serna María Fernanda, Suarez-Ortegón Milton Fabián, Jiménez-Charris Eliécer, Echeverri Isabella, Cala Mónica P, Mosquera Mildrey
Grupo de Nutrición, Departamento de Ciencias Fisiológicas, Facultad de Salud, Universidad del Valle, Calle 4B #36-00 Cali, Colombia.
Departamento de Alimentación y Nutrición, Facultad de Ciencias de La Salud, Pontificia Universidad Javeriana Seccional Cali, Colombia. Cl. 18 #118-250, Barrio Pance, 760031 Cali, Valle del Cauca Colombia.
J Diabetes Metab Disord. 2024 May 4;23(1):1279-1292. doi: 10.1007/s40200-024-01423-5. eCollection 2024 Jun.
Metabolic syndrome (MetS) comprises a set of risk factors that contribute to the development of chronic and cardiovascular diseases, increasing the mortality rate. Altered lipid metabolism is associated with the development of metabolic disorders such as insulin resistance, obesity, atherosclerosis, and metabolic syndrome; however, there is a lack of knowledge about lipids compounds and the lipidic pathways associated with this condition, particularly in the Latin-American population. Innovative approaches, such as lipidomic analysis, facilitate the identification of lipid species related to these risk factors. This study aimed to assess the plasma lipidome in subjects with MetS.
This correlation study included healthy adults and adults with MetS. Blood samples were analyzed. The lipidomic profile was determined using an Agilent Technologies 1260 liquid chromatography system coupled to a Q-TOF 6545 quadrupole mass analyzer with electrospray ionization. The main differences were determined between the groups.
The analyses reveal a distinct lipidomic profile between healthy adults and those with MetS, including increased concentrations of most identified glycerolipids -both triglycerides and diglycerides- and decreased levels of ether lipids and sphingolipids, especially sphingomyelins, in MetS subjects. Association between high triglycerides, waist circumference, and most differentially expressed lipids were found.
Our results demonstrate dysregulation of lipid metabolism in subjects with Mets, supporting the potential utility of plasma lipidome analysis for a deeper understanding of MetS pathophysiology.
The online version contains supplementary material available at 10.1007/s40200-024-01423-5.
代谢综合征（MetS）包含一系列导致慢性疾病和心血管疾病发生、增加死亡率的风险因素。脂质代谢改变与胰岛素抵抗、肥胖、动脉粥样硬化和代谢综合征等代谢紊乱的发生有关；然而，对于与这种情况相关的脂质化合物和脂质途径，尤其是拉丁裔人群，我们了解不足。脂质组学分析等创新方法有助于识别与这些风险因素相关的脂质种类。本研究旨在评估代谢综合征患者的血浆脂质组。
这项相关性研究纳入了健康成年人和患有代谢综合征的成年人。对血液样本进行了分析。使用配备电喷雾电离的安捷伦科技1260液相色谱系统与Q-TOF 6545四极杆质谱分析仪联用，测定脂质组图谱。确定了两组之间的主要差异。
分析显示，健康成年人与代谢综合征患者之间存在明显不同的脂质组图谱，包括在代谢综合征患者中，大多数已鉴定的甘油酯（甘油三酯和甘油二酯）浓度增加，醚脂和鞘脂水平降低，尤其是鞘磷脂。发现高甘油三酯、腰围与大多数差异表达脂质之间存在关联。
我们的结果表明代谢综合征患者存在脂质代谢失调，支持血浆脂质组分析对于深入了解代谢综合征病理生理学的潜在效用。
在线版本包含可在10.1007/s40200-024-01423-5获取的补充材料。
