Golshan-Tafti Mohammad, Bahrami Reza, Dastgheib Seyed Alireza, Karimi-Zarchi Mojgan, Azizi Sepideh, Marzbanrad Zahra, Hajizadeh Nazanin, Aghasipour Maryam, Yeganegi Maryam, Shiri Amirmasoud, Aghili Kazem, Neamatzadeh Hossein
Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran.
Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
J Diabetes Metab Disord. 2024 Apr 18;23(1):475-486. doi: 10.1007/s40200-024-01428-0. eCollection 2024 Jun.
The genetic aspect of gestational diabetes mellitus (GDM) is influenced by multiple causal genetic variants, each with different effect sizes. The KCNJ11 gene is particularly noteworthy as a potential contributor to the risk of GDM due to its role in regulating glucose-induced insulin secretion. To evaluate the association between KCNJ11 polymorphisms and GDM, a comprehensive meta-analysis was conducted to review the existing literature and quantitatively assess the correlation.
A thorough search was performed on the PubMed, EMBASE, Scopus, and CNKI databases until December 25, 2023, using precise terms and keywords related to Gestational Diabetes, KCNJ11 gene, and polymorphism. Odds ratios and 95% confidence intervals were used to evaluate the relationships. The statistical analysis was conducted using Comprehensive Meta-Analysis software, and the Cochrane risk of bias assessment tool was used to determine bias presence.
The meta-analysis comprised 9 studies with 3108 GDM cases and 5374 controls for the rs5219 polymorphism, and 3 studies with 1209 GDM cases and 1438 controls for the rs5210 polymorphism. The pooled data indicated a noteworthy link between the rs5219 polymorphism and GDM globally and among various ethnic groups, notably in Caucasian and Asian populations. However, no substantial association was observed between the rs5210 polymorphism and GDM.
Pooled data showed a correlation between the KCNJ11 rs5219 polymorphism and GDM susceptibility, but no association was found for the rs5210 polymorphism. Future research with larger sample sizes and more diverse populations is needed to improve result generalizability.
The online version contains supplementary material available at 10.1007/s40200-024-01428-0.
妊娠期糖尿病（GDM）的遗传因素受多种因果遗传变异影响，每个变异的效应大小不同。KCNJ11基因因其在调节葡萄糖诱导的胰岛素分泌中的作用，作为GDM风险的潜在贡献者尤其值得关注。为评估KCNJ11基因多态性与GDM之间的关联，进行了一项全面的荟萃分析以回顾现有文献并定量评估相关性。
截至2023年12月25日，在PubMed、EMBASE、Scopus和中国知网数据库中进行了全面检索，使用与妊娠期糖尿病、KCNJ11基因和多态性相关的精确术语和关键词。采用比值比和95%置信区间来评估关系。使用综合荟萃分析软件进行统计分析，并使用Cochrane偏倚风险评估工具来确定是否存在偏倚。
荟萃分析纳入了9项研究，其中3108例GDM病例和5374例对照用于rs5219多态性分析，3项研究，1209例GDM病例和1438例对照用于rs5210多态性分析。汇总数据表明，rs5219多态性与全球及不同种族的GDM之间存在显著关联，尤其是在白种人和亚洲人群中。然而，未观察到rs5210多态性与GDM之间存在实质性关联。
汇总数据显示KCNJ11基因rs5219多态性与GDM易感性之间存在相关性，但未发现rs5210多态性与GDM有关联。需要开展样本量更大、人群更多样化的未来研究，以提高结果的普遍性。
在线版本包含可在10.1007/s40200-024-01428-0获取的补充材料。
