Li Xinsi, Li Qian, Wang Li, Ding Huifen, Wang Yizhong, Liu Yunfei, Gong Ting
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University, Chongqing, China.
Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical University, Chongqing, China.
Front Cardiovasc Med. 2024 Jun 12;11:1406220. doi: 10.3389/fcvm.2024.1406220. eCollection 2024.
Atherosclerosis (AS) is a complex disease caused by multiple pathological factors threatening human health-the pathogenesis is yet to be fully elucidated. In recent years, studies have exhibited that the onset of AS is closely involved with oral and gut microbiota, which may initiate or worsen atherosclerotic processes through several mechanisms. As for how the two microbiomes affect AS, existing mechanisms include invading plaque, producing active metabolites, releasing lipopolysaccharide (LPS), and inducing elevated levels of inflammatory mediators. Considering the possible profound connection between oral and gut microbiota, the effect of the interaction between the two microbiomes on the initiation and progression of AS has been investigated. Findings are oral microbiota can lead to gut dysbiosis, and exacerbate intestinal inflammation. Nevertheless, relevant research is not commendably refined and a concrete review is needed. Hence, in this review, we summarize the most recent mechanisms of the oral microbiota and gut microbiota on AS, illustrate an overview of the current clinical and epidemiological evidence to support the bidirectional connection between the two microbiomes and AS.
动脉粥样硬化（AS）是一种由多种病理因素引起的复杂疾病，威胁着人类健康，其发病机制尚未完全阐明。近年来，研究表明AS的发病与口腔和肠道微生物群密切相关，它们可能通过多种机制引发或加剧动脉粥样硬化进程。至于这两种微生物群如何影响AS，现有的机制包括侵入斑块、产生活性代谢产物、释放脂多糖（LPS）以及诱导炎症介质水平升高。考虑到口腔和肠道微生物群之间可能存在的深远联系，已经对这两种微生物群之间的相互作用对AS发生和发展的影响进行了研究。研究结果表明口腔微生物群可导致肠道生态失调，并加剧肠道炎症。然而，相关研究尚不够完善，需要进行具体的综述。因此，在本综述中，我们总结了口腔微生物群和肠道微生物群对AS的最新作用机制，阐述了支持这两种微生物群与AS之间双向联系的当前临床和流行病学证据概况。
