Wang Tao, Fu Zhong-Yu, Li Yan-Juan, Zi Lei, Song Cheng-Zhu, Tao Yu-Xuan, Zhang Mei, Gu Wen, Yu Jie, Yang Xing-Xin
College of Pharmaceutical Science, Yunnan University of Chinese Medicine, 1076 Yuhua Road, Kunming 650500, China.
Yunnan Key Laboratory of Southern Medicine Utilization, 1076 Yuhua Road, Kunming 650500, China.
Saudi Pharm J. 2024 Jul;32(7):102124. doi: 10.1016/j.jsps.2024.102124. Epub 2024 Jun 2.
Natural products (NPs) play an irreplaceable role in the intervention of various diseases and have been considered a critical source of drug development. Many new pharmacodynamic compounds with potential clinical applications have recently been derived from NPs. These compounds range from small molecules to polysaccharides, polypeptides, proteins, self-assembled nanoparticles, and extracellular vesicles. This review summarizes various active substances found in NPs. The investigation of active substances in NPs can potentiate new drug development and promote the in-depth comprehension of the mechanism of action of NPs that can be beneficial in the prevention and treatment of human diseases.
天然产物在各种疾病的干预中发挥着不可替代的作用,并且一直被视为药物开发的关键来源。最近,许多具有潜在临床应用价值的新药效化合物都源自天然产物。这些化合物涵盖了从小分子到多糖、多肽、蛋白质、自组装纳米颗粒和细胞外囊泡等多种类型。本综述总结了天然产物中发现的各种活性物质。对天然产物中活性物质的研究可以加强新药开发,并促进对天然产物作用机制的深入理解,这有助于人类疾病的预防和治疗。