恶性疟原虫在体外被人类“危机”血清和氯喹损伤后的发育及超微结构
The development and ultrastructure of Plasmodium falciparum damaged in vitro by human "crisis" sera and by chloroquine.
作者信息
Butcher G A, Maxwell L, Cowen N, Clancy R L, Stace J D
出版信息
Aust J Exp Biol Med Sci. 1985 Feb;63 ( Pt 1):9-18. doi: 10.1038/icb.1985.2.
PMID:3893406
Abstract
P. falciparum malaria was cultured in vitro in the presence of sera from patients with cerebral malaria, meningitis and also after chloroquine administration. Intra-erythrocytic parasite damage was seen by light and electron microscopy. The significance of the results is discussed with relevance to non-specific immune mechanisms, and the damage induced by these mechanisms compared with that from chloroquine.
摘要
恶性疟原虫在来自脑型疟疾、脑膜炎患者的血清存在的情况下以及在给予氯喹之后进行体外培养。通过光学显微镜和电子显微镜观察红细胞内寄生虫的损伤情况。结合非特异性免疫机制对结果的意义进行了讨论，并将这些机制诱导的损伤与氯喹诱导的损伤进行了比较。
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