[在喀麦隆南部使用简化的体内7天试验评估恶性疟原虫对氯喹和氨酚喹的敏感性]
[Evaluation of Plasmodium falciparum susceptibility to chloroquine and amodiaquine using a simplified, in vivo, 7-day test in southern Cameroon].
作者信息
Gazin P, Louis J P, Mulder L, Eberle F, Jambou R, Hengy C
机构信息
Service d'Entomologie Médicale, l'Organisation de Coordination pour la lutte contre les grandes Endémies en Afrique Centrale (OCEAC), Yaoundé Cameroun.
出版信息
Med Trop (Mars). 1990 Jan-Mar;50(1):27-31.
Plasmodium falciparum susceptibility to chloroquine and amodiaquine at a posology of 25 mg/kg per os in 3 days was evaluated in the pupils of 6 primary schools of South-West Cameroon during the first semester 1989. Parasitic index was 75%. Plasmodium falciparum was present in 96% of the infections 24% of the 357 children treated with chloroquine were carriers of trophozoites at D3 and 17% at D7. Complete resistance, at level R III, was observed in 4% of the children. By the 55 children treated with amodiaquine, 13% and 10% were carriers of few trophozoites at D3 and D7. The significance of these results is discussed.
1989年第一学期，在喀麦隆西南部6所小学的学生中评估了恶性疟原虫对氯喹和氨酚喹的敏感性，口服剂量为25mg/kg，持续3天。寄生虫指数为75%。96%的感染病例中存在恶性疟原虫。在接受氯喹治疗的357名儿童中，24%在第3天是滋养体携带者，17%在第7天是滋养体携带者。4%的儿童观察到完全耐药，即R III级耐药。在接受氨酚喹治疗的55名儿童中，13%和10%在第3天和第7天是少量滋养体携带者。讨论了这些结果的意义。
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