Litvinova Larisa Sergeevna, Vulf Maria Aleksandrovna, Yurova Kristina Alekseevna, Khaziakhmatova Olga Gennadievna, Malashchenko Vladimir, Bograya Maria, Kozlov Ivan, Todosenko Natalia
Center of Immunology and Cellular Biotechnology, Department of Basic Laboratory of Immunology and Cell Biotechnology, Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Moscow.
Curr Med Chem. 2025;32(15):3006-3027. doi: 10.2174/0109298673309247240610050423.
Metabolic syndrome (MetS) is a complex of serious pathologies with a high prevalence worldwide. Disruption of mitochondrial biogenesis and its interaction with other cell organelles plays an important role in the development of MetS. Studies have revealed the phenotypic and functional heterogeneity of mitochondria that exist within a single cell and can regulate metabolic signaling pathways, influencing the development of metabolic diseases. Excessive intake of fatty acids leads to changes in fatty acid metabolism that affect the biology of important cell organelles - the lipid droplets, whose specific biology is not fully understood. Perhaps targeted molecular genetic stimulation aimed at regulating the contact between mitochondria and lipids can break the vicious cycle of inflammation in MetS and restore normal cell function, reducing the risk of developing concomitant pathologies. The review describes potential (promising) therapeutic molecular targets associated with mitochondria and lipid droplets, focusing on the proteins involved in their contact and emphasizing their role in the pathogenesis of MetS.
代谢综合征（MetS）是一种在全球范围内具有高患病率的复杂严重病理状态。线粒体生物合成的破坏及其与其他细胞器的相互作用在代谢综合征的发展中起着重要作用。研究揭示了存在于单个细胞内的线粒体的表型和功能异质性，其可调节代谢信号通路，影响代谢性疾病的发展。脂肪酸的过量摄入会导致脂肪酸代谢的变化，进而影响重要细胞器——脂滴的生物学特性，而脂滴的具体生物学特性尚未完全明确。或许旨在调节线粒体与脂质之间接触的靶向分子遗传刺激能够打破代谢综合征中的炎症恶性循环，恢复细胞正常功能，降低并发疾病的发生风险。这篇综述描述了与线粒体和脂滴相关的潜在（有前景的）治疗分子靶点，重点关注参与它们接触的蛋白质，并强调它们在代谢综合征发病机制中的作用。
