脂肪组织中线粒体相关调控与肥胖干预的潜在试剂
Mitochondria-associated regulation in adipose tissues and potential reagents for obesity intervention.
机构信息
Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
School of Medical and Life Sciences/Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
出版信息
Front Endocrinol (Lausanne). 2023 Jun 16;14:1132342. doi: 10.3389/fendo.2023.1132342. eCollection 2023.
INTRODUCTION
A systematic review analysis was used to assess the profile of mitochondrial involvement in adipose tissue regulation and potential reagents to intervene in obesity through the mitochondrial pathway.
METHODS
Three databases, PubMed, Web of Science, and Embase, were searched online for literature associated with mitochondria, obesity, white adipose tissue, and brown adipose tissue published from the time of their creation until June 22, 2022, and each paper was screened.
RESULTS
568 papers were identified, of which 134 papers met the initial selection criteria, 76 were selected after full-text review, and 6 were identified after additional searches. A full-text review of the included 82 papers was performed.
CONCLUSION
Mitochondria play a key role in adipose tissue metabolism and energy homeostasis, including as potential therapeutic agents for obesity.
简介
本系统综述分析评估了线粒体在脂肪组织调节中的作用，以及通过线粒体途径干预肥胖的潜在试剂。
方法
在线检索了 PubMed、Web of Science 和 Embase 三个数据库，检索了与线粒体、肥胖、白色脂肪组织和棕色脂肪组织相关的文献，检索时间从数据库建立开始到 2022 年 6 月 22 日，并对每篇文献进行筛选。
结果
共确定了 568 篇文献，其中 134 篇符合初始选择标准，76 篇经过全文审查后入选，另外 6 篇通过进一步检索确定。对纳入的 82 篇文献进行了全文审查。
结论
线粒体在脂肪组织代谢和能量平衡中起着关键作用，包括作为肥胖治疗药物的潜在作用。
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