Department of Nursing Administration, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
J Cancer Res Ther. 2024 Aug 1;20(4):1334-1337. doi: 10.4103/jcrt.jcrt_2172_23. Epub 2024 Aug 29.
Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer-related deaths globally, with a five-year survival rate of only 5%.
Pancreatic ductal adenocarcinoma is often fatal because of the lack of specific early symptoms and effective early screening tools. Therefore, 80%-85% of patients are usually diagnosed in the advanced stages. This study aimed to investigate the analgesic effect of transcutaneous electrical acupoint stimulation in patients with advanced pancreatic cancer.
Eighty patients with advanced pancreatic cancer were recruited from the Integrative Medicine Department of our hospital between June 2017 and October 2018 and randomly divided into the experimental group ( n = 40) and the control group ( n = 40). The experimental group received transcutaneous electrical acupoint stimulation combined with analgesic medication for 3 consecutive days, while the control group received only analgesic medication. The pain scores of the two groups before and after intervention were compared.
The mean pain severity score was significantly lower in the experimental group than in the control group on day 1 ( P < 0.001), day 2 ( P < 0.001), day 3 ( P = 0.005), and day 4 ( P = 0.043).
Transcutaneous electrical acupoint stimulation therapy effectively alleviates the pain of patients with advanced pancreatic cancer with a high degree of safety and minimal adverse effects, and is worthy of clinical application.
全球范围内，胰腺癌是导致癌症相关死亡的第四大原因，其五年生存率仅为 5%。
由于缺乏特异性的早期症状和有效的早期筛查工具，胰腺癌通常是致命的。因此，80%-85%的患者通常在晚期被诊断出来。本研究旨在探讨经皮穴位电刺激对晚期胰腺癌患者的镇痛效果。
2017 年 6 月至 2018 年 10 月，我院整合医学科共招募 80 例晚期胰腺癌患者，随机分为实验组（n=40）和对照组（n=40）。实验组接受经皮穴位电刺激联合镇痛药物治疗连续 3 天，对照组仅接受镇痛药物治疗。比较两组患者干预前后的疼痛评分。
实验组患者在干预后第 1 天（ P < 0.001）、第 2 天（ P < 0.001）、第 3 天（ P = 0.005）及第 4 天（ P = 0.043）的疼痛严重程度评分均显著低于对照组。
经皮穴位电刺激疗法能有效缓解晚期胰腺癌患者的疼痛，具有较高的安全性和极小的不良反应，值得临床应用。
