Sanders J E, Thomas E D, Buckner C D, Flournoy N, Stewart P S, Clift R A, Lum L, Bensinger W I, Storb R, Appelbaum F R
Blood. 1985 Aug;66(2):460-2.
Thirty-eight children between the ages of 0.8 and 17 years with acute nonlymphoblastic leukemia in first remission induced by chemotherapy were given cyclophosphamide, total body irradiation, and bone marrow transplants from HLA-matched donors. Six patients died of pneumonia, one died of metabolic problems, and one died of chronic graft-v-host disease complications. Five patients relapsed between six months and 3.2 years after transplantation. Three of the five died of leukemia, one survives with leukemia three years after transplantation, and one survives in remission off treatment following chemotherapy for 22 months. Twenty-five survive in continuous remission from 1.7 to 8.4 years after transplantation, and the actuarial analysis shows a disease-free survival rate of 64%, with a plateau extending from 3.5 to 8.4 years. All lead normal lives.
38名年龄在0.8岁至17岁之间、因化疗诱导处于首次缓解期的急性非淋巴细胞白血病患儿接受了环磷酰胺、全身照射以及来自HLA匹配供者的骨髓移植。6名患者死于肺炎，1名死于代谢问题，1名死于慢性移植物抗宿主病并发症。5名患者在移植后6个月至3.2年复发。5名患者中的3名死于白血病，1名移植后3年仍患白血病存活，1名在接受化疗22个月后停止治疗处于缓解期存活。25名患者在移植后1.7年至8.4年持续缓解存活，精算分析显示无病生存率为64%，3.5年至8.4年为平台期。所有患者均过着正常生活。
