Diawara Abdoulaye, Coulibaly Djibril Mamadou, Kone Drissa, Traore Mama A, Konaté Drissa, Bazi Dicko S, Kassogue Oumar, Sylla Djeneba, Fofana Fatoumata Gniné, Diabaté Oudou, Traore Mariam, Nieantao Ibrahim Antoine, Keїta Kaly, Diarra Mamadou, Smith Olivia, Li Jian, Cisse Cheickna, Abbas Talib Yusuf, Zheng Crystal, Fatumo Segun, Traore Kassim, Wele Mamadou, Diakité Mahamadou, Doumbia Seydou O, Shaffer Jeffrey G
University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
National Federation of Community Health Associations, Bamako, Mali.
J Diabetes Mellitus. 2024 May;14(2):133-152. doi: 10.4236/jdm.2024.142012. Epub 2024 May 31.
Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be captured through routine surveillance. This study aimed to characterize the prevalence and demo-graphic profile of dyslipidemia in T2D in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and serological analyses. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex ( = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status ( = .013 and.036, respectively). High total and high LDL-C parameters were significantly associated with hypertension ( = .029 and .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concomitant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.
血脂异常是一种血液中脂质浓度异常循环的病症。这种病症在2型糖尿病（T2D）患者中很常见，并与T2D的合并症相关，尤其是心血管疾病。T2D患者的血脂异常通常表现为血浆甘油三酯升高和高密度脂蛋白胆固醇（HDL-C）水平降低。在非洲农村地区，关于血脂异常的文献存在显著空白，因为通过常规监测可能无法获取血脂谱。本研究旨在描述马里加纳杜古农村社区T2D患者血脂异常的患病率和人口统计学特征。2021年11月至2022年3月期间，我们对加纳杜古的104名T2D患者进行了横断面研究。通过横断面调查和血清学分析收集了人口统计学和血脂谱数据。T2D患者血脂异常的总体患病率为87.5%（91/104），男女患病率无差异（P = 0.368）。低密度脂蛋白胆固醇（LDL-C）升高是最常见的血脂异常（78.9%，[82/104]）。血脂异常与年龄和高血压状态相关（分别为P = 0.013和0.036）。总胆固醇升高和LDL-C升高参数与高血压显著相关（分别为P = 0.029和0.006）。在马里农村等资源匮乏地区，迫切需要改善常规血脂异常筛查的基础设施，以指导其预防和干预措施。在加纳杜古观察到的高血脂异常率，与非洲心血管疾病的相应增加一致，这表明血脂谱评估应纳入非洲农村地区T2D患者的常规医疗护理中。
