Al Ghadeer Hussain A, Al Barqi Mohammed, Almaqhawi Abdullah, Alsultan Amal S, Alghafli Jinan A, AlOmaish Murtada A, AlGhanem Zuhur A, Alsaqar Amer H, Alatiyyah Abrar T, Alburayh Yasamiyan A, AlOmair Abdulatif, Almuhaysin Afaf I, Alsaeed Ali A
Paediatrics, Maternity and Children Hospital, Al-Ahsa, SAU.
Family and Community Medicine, King Faisal University, Al-Ahsa, SAU.
Cureus. 2021 Dec 6;13(12):e20222. doi: 10.7759/cureus.20222. eCollection 2021 Dec.
Diabetes mellitus (DM), a chronic metabolic noncommunicable disease (NCD), has assumed epidemic proportions worldwide. Type 2 diabetes (T2D) is defined as chronic high blood glucose levels due to the deficiency of insulin or resistance to it. Dyslipidemia is one of the major causes of cardiovascular diseases in patients with T2D. It is characterized by elevated plasma triglyceride (TG), low high-density lipoprotein (HDL) cholesterol, and high low-density lipoprotein (LDL) cholesterol, which is mostly present in patients with DM.
We conducted a retrospective cross-sectional study at the King Faisal University (KFU) Health Center in the eastern region of Saudi Arabia. The data of patients from October 2014 to February 2021 were collected. We collected the patients' data from the KFU Health Center after obtaining approval from the KFU polyclinic administration. Prior ethical approval was taken from the Institutional Review Board of Ethics and Research Committee in the College of Medicine, KFU (approval number, 2020-10-62). We collected patients' data, including their gender, age, nationality, and blood analysis (lipids profile - TGs, HDL, LDL, and hemoglobin A1c [HbA1c] levels).
This study included 191 patients with T2D, 137 (71.7%) were from Saudi Arabia, and 54 (28.3%) were from other countries. Patients' age ranged from 21 to 100 years, with a mean age of 56.2 ± 11.8 years. There were 107 (56%) females. Cholesterol levels ranged from 102 to 300 mg/dl with a mean value of 187.3 mg/dl.
In the current study, we assessed the association between HbA1c levels and lipid profiles in patients with T2D at the KFU Health Center in the eastern region of the Kingdom of Saudi Arabia. Our results on the adjusted relationship of HbA1c with lipid profile through regression model have demonstrated that HDL alone had significant adjusted relation with HbA1c if other factors are kept constant. We suggest focusing on TC and HDL levels in T2D health management in future studies.
糖尿病（DM）是一种慢性代谢性非传染性疾病（NCD），在全球范围内已呈流行态势。2型糖尿病（T2D）的定义是由于胰岛素缺乏或对胰岛素抵抗导致的慢性高血糖水平。血脂异常是T2D患者心血管疾病的主要原因之一。其特征是血浆甘油三酯（TG）升高、高密度脂蛋白（HDL）胆固醇降低以及低密度脂蛋白（LDL）胆固醇升高，这在糖尿病患者中大多存在。
我们在沙特阿拉伯东部地区的法赫德国王大学（KFU）健康中心进行了一项回顾性横断面研究。收集了2014年10月至2021年2月期间患者的数据。在获得KFU综合诊所管理部门的批准后，我们从KFU健康中心收集了患者的数据。事先已获得KFU医学院伦理与研究委员会机构审查委员会的伦理批准（批准号，2020 - 10 - 62）。我们收集了患者的数据，包括他们的性别、年龄、国籍以及血液分析（血脂谱 - TG、HDL、LDL和糖化血红蛋白[HbA1c]水平）。
本研究纳入了191例T2D患者，其中137例（71.7%）来自沙特阿拉伯，54例（28.3%）来自其他国家。患者年龄在21岁至100岁之间，平均年龄为56.2±11.8岁。有107例（56%）女性。胆固醇水平在102至300mg/dl之间，平均值为187.3mg/dl。
在本研究中，我们评估了沙特阿拉伯王国东部地区KFU健康中心T2D患者的HbA1c水平与血脂谱之间的关联。我们通过回归模型对HbA1c与血脂谱的调整关系的结果表明，如果其他因素保持不变，仅HDL与HbA1c有显著的调整关系。我们建议在未来的研究中，在T2D健康管理中关注总胆固醇（TC）和HDL水平。
