Zhu Conglin, Wang Kaizhi, Gao Feifan, Sun Zehui, Chen Mugeng, Fei Jiachen, Chen Chen, He Heyong, Liu Yongmei, Cao Yong
Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China.
Chem Commun (Camb). 2024 Jul 16;60(58):7483-7486. doi: 10.1039/d4cc02474e.
Here we present a hybrid catalytic pathway for efficient synthesis of 5-aminomethyl-2-furancarboxylic acid (AMFC), a bio-based nylon-6 analogue monomer, from 5-hydroxymethylfurfural (HMF). This method combines homogeneous-catalyzed selective oxidation of HMF to 5-formyl-2-furancarboxylic acid (FFCA) with heterogeneous-catalyzed reductive amination using ammonia as the nitrogen source. Through this relay strategy, we achieve significant enhancements in overall efficiency, resulting in isolation yields of up to 92% for highly selective and scalable AMFC production from HMF.
在此，我们展示了一种混合催化途径，用于从5-羟甲基糠醛（HMF）高效合成5-氨甲基-2-呋喃羧酸（AMFC），这是一种生物基尼龙-6类似物单体。该方法将均相催化的HMF选择性氧化为5-甲酰基-2-呋喃羧酸（FFCA）与使用氨作为氮源的非均相催化还原胺化相结合。通过这种接力策略，我们实现了整体效率的显著提高，从HMF生产高选择性且可扩展的AMFC时，分离产率高达92%。
