TRIM65在疾病中的神奇与奥秘。
The Magic and Mystery of TRIM65 in Diseases.
作者信息
Zhou Qinyi, Li Yuan, Zhou Zhixiang, Zhou Yiren, Liu Yizhou, Liu Wang, Ma Xiaofeng
机构信息
Department of Cardiology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
出版信息
Curr Med Chem. 2024 Jun 27. doi: 10.2174/0109298673304966240614091547.
Tripartite-motif protein family member 65 (TRIM65) belongs to the tripartite motif (TRIM) protein family. Its typical structure consists of the RING, B-Box motif, and coiled-coil domains, which are highly conserved at the N-terminus and the variable SPRY domain at the C-terminus. TRIM65 is an E3 ubiquitin ligase that participates in physiological and pathological processes through the ubiquitination pathway, including intracellular signal transduction, protein degradation, cell proliferation, apoptosis, carcinogenesis, autophagy, and phenotypic transformation. Evidence shows that TRIM65 plays a remarkable and obscure role in diseases, including multisystem tumours, neurodegenerative diseases, immune system diseases, and inflammatory diseases. This review is devoted to elaborating on the relationship between TRIM65 and diseases and its pathogenic mechanism, providing a theoretical basis for TRIM65 as a possible pathogenic target of diseases and exploring the possible future research direction of TRIM65 and the challenges it may face.
三联基序蛋白家族成员65（TRIM65）属于三联基序（TRIM）蛋白家族。其典型结构由N端高度保守的RING结构域、B-Box基序和卷曲螺旋结构域以及C端可变的SPRY结构域组成。TRIM65是一种E3泛素连接酶，通过泛素化途径参与生理和病理过程，包括细胞内信号转导、蛋白质降解、细胞增殖、凋亡、致癌作用、自噬和表型转化。有证据表明，TRIM65在多种疾病中发挥着显著而复杂的作用，包括多系统肿瘤、神经退行性疾病、免疫系统疾病和炎症性疾病。本文综述旨在阐述TRIM65与疾病之间的关系及其致病机制，为TRIM65作为疾病可能的致病靶点提供理论依据，并探索TRIM65未来可能的研究方向及其可能面临的挑战。
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