From the Department of Ophthalmology, Ekol Eye Hospital, Izmir, Turkey (Cinar); İzmir Tepecik Training and Research Hospital Ophthalmology Clinic, University of Health Sciences, Izmir, Turkey (Yuce); Department of Ophthalmology, Alaattin Keykubat University, Alanya, Antalya, Turkey (Aslan).
J Cataract Refract Surg. 2024 Nov 1;50(11):1101-1108. doi: 10.1097/j.jcrs.0000000000001511.
To assess corneal sensitivity and the ocular surface in patients undergoing primary femtosecond laser in situ keratomileusis (FS-LASIK) and those undergoing FS-LASIK retreatment under the same flap due to residual refractive error.
Ekol Eye Hospital, Izmir, Turkey.
Prospective case series.
19 patients with previous FS-LASIK who had myopic and astigmatic refractive error were included in the study group, and 19 age-matched and sex-matched patients undergoing FS-LASIK for the first time as the control group. Corneal sensitivity, Schirmer test, tear film break-up time (TBUT), Oxford grading scheme for ocular surface staining, and Ocular Surface Disease Index (OSDI) were measured preoperatively and at postoperative 1 week and 1, 3, and 6 months.
The mean refractive correction in the study and control groups, respectively, was 2.18 ± 0.78 diopters (D) (range: 1.00 to 3.50) and 2.76 ± 1.20 D (range: 1.00 to 4.50; P = .07). Corneal esthesiometry results in the study and control groups, respectively, were 6.10 ± 12.55 vs 9.90 ± 11.50 mm at 1 week ( P = .001), 41.95 ± 6.98 vs 45.09 ± 5.88 mm at 1 month ( P = .004), 56.09 ± 3.37 vs 56.19 ± 2.52 mm at 3 months ( P = .8), and 58.60 ± 2.01 vs 58.80 ± 1.39 mm at 6 months ( P = .5). Significant difference between the 2 groups in Schirmer test score that disappeared at postoperative 3 months and in TBUT and ocular surface staining that disappeared at 6 months, whereas the statistically significant difference in OSDI score persisted at 6 months ( P = .03) was detected.
Corneal surface sensitivity and ocular surface health are more impaired in patients undergoing FS-LASIK retreatment due to residual refractive error.
评估因残余屈光不正而接受初次飞秒激光原位角膜磨镶术（FS-LASIK）和因同一瓣而接受 FS-LASIK 翻修的患者的角膜敏感性和眼表。
土耳其伊兹密尔 Ekol 眼科医院。
前瞻性病例系列。
研究组纳入 19 例曾行 FS-LASIK 治疗的近视和散光患者，对照组纳入 19 例初次行 FS-LASIK 治疗的年龄和性别匹配患者。分别于术前、术后 1 周以及术后 1、3 和 6 个月时，测量角膜敏感度、泪液分泌试验、泪膜破裂时间（TBUT）、牛津眼表面染色分级方案和眼表面疾病指数（OSDI）。
研究组和对照组的平均屈光矫正值分别为 2.18 ± 0.78 屈光度（D）（范围：1.00 至 3.50）和 2.76 ± 1.20 D（范围：1.00 至 4.50；P =.07）。研究组和对照组的角膜感觉测量结果分别为：术后 1 周时为 6.10 ± 12.55 毫米与 9.90 ± 11.50 毫米（P =.001），术后 1 个月时为 41.95 ± 6.98 毫米与 45.09 ± 5.88 毫米（P =.004），术后 3 个月时为 56.09 ± 3.37 毫米与 56.19 ± 2.52 毫米（P =.8），术后 6 个月时为 58.60 ± 2.01 毫米与 58.80 ± 1.39 毫米（P =.5）。术后 3 个月时，Schirmer 试验评分和 TBUT 的组间差异消失，6 个月时眼表面染色的组间差异消失，但 OSDI 评分的组间差异在 6 个月时仍然显著（P =.03）。
因残余屈光不正而接受 FS-LASIK 翻修的患者，角膜表面敏感性和眼表健康状况受损更严重。
