适体辅助噬菌体展示：利用靶向单个PD-L1蛋白上不同位点的肽和适体增强检查点抑制作用。
Aptamer-assisted phage display: enhancing checkpoint inhibition with a peptide and an aptamer targeting distinct sites on a single PD-L1 protein.
作者信息
Arya Satya Prakash, Thennakoon Siddhartha Kalpa Samadhi, Phuoc Chien Minh Tran, Silwal Achut Prasad, Jahan Raunak, Postema Rick Mason, Timilsina Hari, Reynolds Andrew Michael, Tan Xiaohong
机构信息
Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA.
出版信息
Chem Commun (Camb). 2024 Jul 18;60(59):7570-7573. doi: 10.1039/d4cc02132k.
Utilizing a novel approach known as aptamer-assisted phage display (APD), we identified an anti-PD-L1 peptide, NV Pep, capable of simultaneous binding to PD-L1 alongside the DNA aptamer MJ5C. Combined inhibition using NV Pep and MJ5C demonstrated significant enhancement compared to individual ligands against the PD-1/PD-L1 interaction.
利用一种称为适体辅助噬菌体展示（APD）的新方法，我们鉴定出一种抗PD-L1肽NV Pep，它能够与DNA适体MJ5C同时结合PD-L1。与单独使用配体相比，使用NV Pep和MJ5C的联合抑制对PD-1/PD-L1相互作用显示出显著增强。
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