Olson J C, Leslie G A
Dev Comp Immunol. 1985 Spring;9(2):335-42. doi: 10.1016/0145-305x(85)90124-7.
Id-1, an idiotype associated with rat anti-Group A streptococcal carbohydrate (anti-SACHO) antibodies has not been detected in any other tested species immunized with Group A streptococcal vaccine (GASV). The immunization of chickens with rat Id-1 prior to challenge with GASV, however, induced the production of Id-1 and anti-Id-1 in some chickens. The concentrations of both idiotype and anti-idiotype were regulated by challenges with GASV. Thus, it appears that this non-mammalian species has the genetic potential to express the mammalian Id-1 network but such a potential is normally masked by regulatory pressures.
Id-1，一种与大鼠抗A组链球菌碳水化合物（抗SACHO）抗体相关的独特型，在用A组链球菌疫苗（GASV）免疫的任何其他受试物种中均未检测到。然而，在用GASV攻击之前用大鼠Id-1免疫鸡，在一些鸡中诱导了Id-1和抗Id-1的产生。独特型和抗独特型的浓度均受GASV攻击的调节。因此，似乎这种非哺乳动物物种具有表达哺乳动物Id-1网络的遗传潜力，但这种潜力通常被调节压力所掩盖。
