Olson J C, Leslie G A
Immunogenetics. 1981;13(1-2):39-56. doi: 10.1007/BF00524604.
The production of Id-1, a cross-reactive idiotype associated with rat anti-group. A streptococcal carbohydrate antibodies, by 11 strains of rats indicates that genes coding for Id-1 are in the germline. Its expression, however, follows a complex inheritance pattern. It was our intent in these studies to determine if immune responsiveness of streptococcus (GASV) immunized females could alter Id-1 expression of GASV-immunized progeny, and, in turn, introduce complications in Id-1 inheritance patterns. - We observed that Id-1-specific immune reactivity of GASV-immunized females could induce significant alterations in Id-1 production by progeny. The relationship between maternal and progeny Id-1 was complex, reflecting the complexity of autologous regulation of Id-1 production, and could be the opposite of what one would predict based upon parental transfer of Id-1 regulatory genes. The nongenetic nature of the maternal regulatory influence was confirmed by foster-mother studies. - We conclude that antigen-induced maternal immune responsiveness can exert a permanent regulatory influence on idiotype expression by progeny and consequently introduce error in to the interpretations of idiotype inheritance patterns. The recognition of this maternal regulatory influence also lends further support to Jerne's hypothesis that idiotype-specific immune networks play a significant role in the regulation of immune responsiveness in vivo.
与大鼠抗群体A链球菌碳水化合物抗体相关的交叉反应独特型Id-1，由11株大鼠产生，这表明编码Id-1的基因存在于种系中。然而，其表达遵循复杂的遗传模式。在这些研究中，我们的目的是确定经A群链球菌（GASV）免疫的雌性大鼠的免疫反应性是否会改变经GASV免疫的子代的Id-1表达，进而在Id-1遗传模式中引入复杂性。——我们观察到，经GASV免疫的雌性大鼠的Id-1特异性免疫反应性可诱导子代Id-1产生显著改变。母代与子代Id-1之间的关系很复杂，反映了Id-1产生的自身调节的复杂性，并且可能与基于Id-1调节基因的亲代传递所预测的情况相反。代母研究证实了母代调节影响的非遗传性质。——我们得出结论，抗原诱导的母代免疫反应性可对子代独特型表达施加永久性调节影响，从而在独特型遗传模式的解释中引入误差。对这种母代调节影响的认识也进一步支持了耶尔恩的假说，即独特型特异性免疫网络在体内免疫反应性调节中起重要作用。
