多发性硬化及相关疾病中的新型成像标志物：隐匿性炎症与中央静脉征
New Imaging Markers in Multiple Sclerosis and Related Disorders: Smoldering Inflammation and the Central Vein Sign.
作者信息
Hemond Christopher C, Gaitán María I, Absinta Martina, Reich Daniel S
机构信息
Department of Neurology, University of Massachusetts Memorial Medical Center and University of Massachusetts Chan Medical School, Worcester, MA, USA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
出版信息
Neuroimaging Clin N Am. 2024 Aug;34(3):359-373. doi: 10.1016/j.nic.2024.03.004. Epub 2024 Apr 23.
Concepts of multiple sclerosis (MS) biology continue to evolve, with observations such as "progression independent of disease activity" challenging traditional phenotypic categorization. Iron-sensitive, susceptibility-based imaging techniques are emerging as highly translatable MR imaging sequences that allow for visualization of at least 2 clinically useful biomarkers: the central vein sign and the paramagnetic rim lesion (PRL). Both biomarkers demonstrate high specificity in the discrimination of MS from other mimics and can be seen at 1.5 T and 3 T field strengths. Additionally, PRLs represent a subset of chronic active lesions engaged in "smoldering" compartmentalized inflammation behind an intact blood-brain barrier.
多发性硬化症（MS）生物学的概念不断演变，诸如“疾病进展与疾病活动无关”等观察结果对传统的表型分类提出了挑战。基于铁敏感性、易感性的成像技术正在成为具有高度可转化性的磁共振成像序列，这些序列能够显示至少两种对临床有用的生物标志物：中央静脉征和顺磁性边缘病变（PRL）。这两种生物标志物在鉴别MS与其他类似疾病时均表现出高特异性，并且在1.5T和3T场强下均可观察到。此外，PRL代表了慢性活动性病变的一个子集，这些病变在完整的血脑屏障后发生“隐匿性”局限性炎症。
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