Escobar J I, Mann J J, Keller J, Wilkins J, Mason B, Mills M J
J Clin Psychiatry. 1985 Aug;46(8 Pt 2):15-9.
The comparative efficacy of molindone and haloperidol, given by injection for the first 2-3 days of hospitalization and then continued orally for up to 4 weeks, is reported from an ongoing double-blind study. Efficacy and side effects were assessed by the Brief Psychiatric Rating Scale, Clinical Global Impressions, Treatment Emergent Symptom Scale, and Target Symptom Ratings. Analyses based on the first 35 patients who entered the study indicate that both drugs were effective and well tolerated. There were slight advantages for molindone early during the injectable phase of treatment and for haloperidol late during the oral portion of the study, but these differences were not clinically significant. No significant differences in side effects were found between the two drugs.
一项正在进行的双盲研究报告了吗茚酮和氟哌啶醇的比较疗效。在住院的头2至3天进行注射给药，然后继续口服给药长达4周。通过简明精神病评定量表、临床总体印象量表、治疗中出现的症状量表和目标症状评定来评估疗效和副作用。基于最初入组研究的35名患者的分析表明，两种药物均有效且耐受性良好。在治疗的注射阶段早期，吗茚酮有轻微优势；在研究的口服阶段后期，氟哌啶醇有轻微优势，但这些差异在临床上并不显著。两种药物在副作用方面未发现显著差异。
