Reschke R W
County of Los Angeles, Mental Health Services, Long Beach Regional Service, 236 E. Third Street, Long Beach, California 90812, USA.
Dis Nerv Syst. 1974 Mar;35(3):112-5.
Intramuscular haloperidol, at three dose levels, (5 mg, 2 mg, and 1 mg) chlorpromazine (25 mg), and placebo were compared for efficacy, rapidity of therapeutic onset, and safety in 50 acute psychotic patients requiring rapid control. The drugs were administered parenterally under double-blind conditions at half-hour intervals until successful control of moderate to very severe symptomatology was achieved or a maximum of four injections had been given. Global evaluation, BPRS, and target symptom ratings were performed. The overall results indicated that the 5 mg and 2 mg haloperidol doses were significantly superior to the 1 mg haloperidol and 25 mg chlorpromazine doses and to placebo. Transfer of patients to oral haloperidol was satisfactorily accomplished. Side effects for all medications were minimal and included slight to moderate EPS and drowsiness. The use of antiparkinson drugs completely controlled the extrapyramidal symptoms.
在50名需要快速控制病情的急性精神病患者中，比较了三种剂量水平的肌肉注射氟哌啶醇（5毫克、2毫克和1毫克）、氯丙嗪（25毫克）和安慰剂在疗效、治疗起效速度及安全性方面的差异。药物在双盲条件下每隔半小时进行一次肠胃外给药，直至中度至非常严重的症状得到成功控制或最多注射四次。进行了整体评估、简明精神病评定量表（BPRS）评估和目标症状评分。总体结果表明，5毫克和2毫克剂量的氟哌啶醇显著优于1毫克剂量的氟哌啶醇、25毫克剂量的氯丙嗪及安慰剂。患者顺利转为口服氟哌啶醇治疗。所有药物的副作用均最小，包括轻微至中度的锥体外系反应（EPS）和嗜睡。使用抗帕金森药物完全控制了锥体外系症状。
