Greenhill L L, Solomon M, Pleak R, Ambrosini P
J Clin Psychiatry. 1985 Aug;46(8 Pt 2):20-5.
Treatment-emergent symptoms and behavioral changes were assessed during an 8-week double-blind study comparing molindone and thioridazine in 31 aggressive hospitalized children (ages 6-11). Molindone was found to be as effective as thioridazine in this sample. Adverse effects differed (nonsignificantly) for the two groups, with more sedation in the thioridazine-treated children. Clinical records from 6 adolescent inpatients treated with molindone were reviewed as a comparison group. Molindone is a relatively safe neuroleptic for child and adolescent inpatients because of its short half-life and minimal prolonged tissue accumulation. Additional studies on different child populations are necessary before the proper indications for molindone usage in the pediatric group can be established.
在一项为期8周的双盲研究中，对31名具有攻击性的住院儿童（6至11岁）比较了吗茚酮和硫利达嗪，期间评估了治疗中出现的症状和行为变化。在该样本中发现吗茚酮与硫利达嗪效果相当。两组的不良反应有所不同（无显著差异），硫利达嗪治疗的儿童镇静作用更强。作为对照组，回顾了6名接受吗茚酮治疗的青少年住院患者的临床记录。吗茚酮因其半衰期短和组织蓄积延长最小，对儿童和青少年住院患者来说是一种相对安全的抗精神病药物。在确定吗茚酮在儿科群体中的正确适应症之前，有必要对不同儿童群体进行更多研究。
