Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Biochem Pharmacol. 2024 Aug;226:116399. doi: 10.1016/j.bcp.2024.116399. Epub 2024 Jun 27.
Diabetes mellitus (DM) is a pervasive global health issue with substantial morbidity and mortality, often resulting in secondary complications, including diabetic wounds (DWs). These wounds, arising from hyperglycemia, diabetic neuropathy, anemia, and ischemia, afflict approximately 15% of diabetic patients, with a considerable 25% at risk of lower limb amputations. The conventional approaches for chronic and diabetic wounds management involves utilizing various therapeutic substances and techniques, encompassing growth factors, skin substitutes and wound dressings. In parallel, emerging cell therapy approaches, notably involving adipose tissue-derived mesenchymal stem cells (ADMSCs), have demonstrated significant promise in addressing diabetes mellitus and its complications. ADMSCs play a pivotal role in wound repair, and their derived exosomes have garnered attention for their therapeutic potential. This review aimed to unravel the potential mechanisms and provide an updated overview of the role of ADMSCs and their exosomes in diabetes mellitus and its associated complications, with a specific focus on wound healing.
糖尿病（DM）是一个普遍存在的全球性健康问题，具有相当高的发病率和死亡率，常常导致继发性并发症，包括糖尿病性伤口（DWs）。这些伤口是由高血糖、糖尿病性神经病、贫血和缺血引起的，大约影响 15%的糖尿病患者，其中相当大的 25%有下肢截肢的风险。慢性和糖尿病性伤口管理的常规方法包括利用各种治疗物质和技术，包括生长因子、皮肤替代品和伤口敷料。与此同时，新兴的细胞治疗方法，特别是涉及脂肪组织来源的间充质干细胞（ADMSCs），在解决糖尿病及其并发症方面显示出了巨大的潜力。ADMSCs 在伤口修复中起着关键作用，其衍生的外泌体因其治疗潜力而受到关注。本综述旨在揭示其潜在的机制，并提供 ADMSCs 及其外泌体在糖尿病及其相关并发症中的作用的最新概述，特别关注伤口愈合。
