恶性疟原虫环状体感染红细胞表面抗原（RESA）在裂殖子和环状体感染红细胞中的定位
Localization of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum in merozoites and ring-infected erythrocytes.
作者信息
Brown G V, Culvenor J G, Crewther P E, Bianco A E, Coppel R L, Saint R B, Stahl H D, Kemp D J, Anders R F
出版信息
J Exp Med. 1985 Aug 1;162(2):774-9. doi: 10.1084/jem.162.2.774.
Abstract
Immunoelectron microscopy with protein A gold has been used to determine the subcellular location of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum. RESA was associated with dense vesicles presumed to be micronemes within merozoites. RESA was not detected on the surface of merozoites but was located at the membrane of erythrocytes infected with ring-stage parasites. RESA within merozoites was largely soluble in the nonionic detergent Triton X-100, but was insoluble in this detergent when associated with the erythrocyte membrane.
摘要
已使用蛋白A金免疫电子显微镜来确定恶性疟原虫环状感染红细胞表面抗原（RESA）的亚细胞定位。RESA与推测为裂殖子内微线体的致密小泡相关。在裂殖子表面未检测到RESA，但它位于被环状期寄生虫感染的红细胞膜上。裂殖子内的RESA在非离子去污剂Triton X - 100中基本可溶，但当与红细胞膜结合时在这种去污剂中不溶。
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