Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, Lodz 90-236, Poland.
Carmen (Cardiometabolism and Nutrition) Laboratory, INSERM Unit 1060, Claude Bernard Lyon-1 University, 165 Chemin du Grand Revoyet, BP12, 69310, Pierre Bénite, France; Hospices Civils of Lyon, Department of Medical Research, Lyon South Hospital, 69310, Pierre Bénite, France.
Trends Endocrinol Metab. 2024 Nov;35(11):931-933. doi: 10.1016/j.tem.2024.06.013. Epub 2024 Jun 29.
Obesity is often associated with adipose tissue (AT) inflammation and immune cell infiltration. Writing recently in Cell Reports, Liao et al. investigated the mechanisms of T cell infiltration of AT using single cell (sc)RNA-sequencing (RNA-seq), transplantation studies, in vitro co-cultures, and knock-out mice. They highlighted the crucial role of C-C motif chemokine ligand 5 (CCL5)-secreting adipose stem cells (ASCs), offering insights for potential therapies.
肥胖通常与脂肪组织 (AT) 炎症和免疫细胞浸润有关。最近，Liao 等人在《Cell Reports》上发表文章，使用单细胞 (sc)RNA 测序 (RNA-seq)、移植研究、体外共培养和基因敲除小鼠研究了 T 细胞浸润 AT 的机制。他们强调了 C-C 基序趋化因子配体 5 (CCL5) 分泌脂肪干细胞 (ASCs) 的关键作用，为潜在的治疗方法提供了思路。
