Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO.
Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO.
Neoreviews. 2024 Jul 1;25(7):e415-e433. doi: 10.1542/neo.25-7-e415.
Bronchopulmonary dysplasia (BPD) is the heterogeneous chronic lung developmental disease of prematurity, which is often accompanied by multisystem comorbidities. Pulmonary vascular disease and pulmonary hypertension (PH) contribute significantly to the pathogenesis and pathophysiology of BPD and dramatically influence the outcomes of preterm infants with BPD. When caring for those patients, clinicians should consider the multitude of phenotypic presentations that fall under the "BPD-PH umbrella," reflecting the need for matching therapies to specific physiologies to improve short- and long-term outcomes. Individualized management based on the patient's prenatal and postnatal risk factors, clinical course, and cardiopulmonary phenotype needs to be identified and prioritized to provide optimal care for infants with BPD-PH.
支气管肺发育不良（BPD）是一种异质性的早产儿慢性肺发育疾病，常伴有多系统合并症。肺血管疾病和肺动脉高压（PH）对 BPD 的发病机制和病理生理学有重要影响，并显著影响伴有 BPD 的早产儿的结局。在照顾这些患者时，临床医生应考虑属于“BPD-PH 伞”下的多种表型表现，这反映了需要根据特定的生理情况匹配治疗方法，以改善短期和长期结局。需要确定并优先考虑基于患者产前和产后危险因素、临床过程和心肺表型的个体化管理，为伴有 BPD-PH 的婴儿提供最佳护理。
