组织学在接受放射治疗的鼻窦癌治疗结果中的作用：单机构经验
The role of histology on the outcome of sinonasal carcinomas treated with radiotherapy: a single institution experience.
作者信息
Kazemian Ali, Farazmand Borna, Taherioun Maryam, Razmkhah Mahdie, Shirkhoda Mohammad, Jalaeefar Amirmohsen, Garajei Ata, Jafari Mehrdad, Heidari Farrokh, Aghili Mahdi, Ghalehtaki Reza
机构信息
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Radiation Oncology Research Center, Cancer Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Radiat Oncol J. 2024 Jun;42(2):116-123. doi: 10.3857/roj.2022.00514. Epub 2024 May 30.
PURPOSE
Sinonasal malignancies are a rare group of head and neck cancers. We aimed to report the oncological outcomes based on histological types in patients who underwent radiotherapy.
MATERIALS AND METHODS
In this single-institution study, we retrospectively retrieved and analyzed data of patients with sinonasal carcinomas who underwent radiotherapy during 2011-2016 as part of their treatment. The 3-year rate of local, regional, and distant recurrences, and overall survival were evaluated according to the histological type.
RESULTS
A total of 28 patients were evaluated in this study, the majority of whom were male (60%). Squamous cell carcinoma (SCC), adenoid cystic carcinoma (ACC), and adenocarcinoma (ADC) were found in 15 patients (53.5%), 8 (28.5%), and 5 (18%), respectively. The highest rates of local and regional recurrences were observed in ACC and SCC, respectively. Distant recurrences were numerically more common in ADC. The 3-year OS was 48%, 50%, and 73% in SCC, ADC, and ACC, respectively.
CONCLUSION
Different histopathologies of sinonasal cancer seem to have different patterns of failure, and this may be considered in the treatment approach.
目的
鼻窦恶性肿瘤是一组罕见的头颈部癌症。我们旨在报告接受放疗患者基于组织学类型的肿瘤学结局。
材料与方法
在这项单机构研究中，我们回顾性检索并分析了2011年至2016年期间接受放疗作为其治疗一部分的鼻窦癌患者的数据。根据组织学类型评估局部、区域和远处复发的3年发生率以及总生存率。
结果
本研究共评估了28例患者，其中大多数为男性（60%）。15例（53.5%）患者为鳞状细胞癌（SCC），8例（28.5%）为腺样囊性癌（ACC），5例（18%）为腺癌（ADC）。局部和区域复发率最高的分别是ACC和SCC。远处复发在ADC中在数值上更为常见。SCC、ADC和ACC的3年总生存率分别为48%、50%和73%。
结论
鼻窦癌不同的组织病理学似乎具有不同的失败模式，在治疗方法中可予以考虑。
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