胶质瘤中癌症促进与治疗的新靶点：肌切蛋白
New targets for cancer promotion and therapy in gliomas: Scinderin.
作者信息
Wang Xi, Luo Lian-Xiang
机构信息
The First Clinical College, Guangdong Medical University, Zhanjiang 524023, Guangdong Province, China.
The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China.
出版信息
World J Clin Oncol. 2024 Jun 24;15(6):687-690. doi: 10.5306/wjco.v15.i6.687.
Glioma is one of the most common primary intracranial tumors, characterized by invasive growth and poor prognosis. Actin cytoskeletal rearrangement is an essential event in tumor cell migration. Scinderin (SCIN), an actin severing and capping protein that regulates the actin cytoskeleton, is involved in the proliferation and migration of certain cancer cells. However, its biological role and molecular mechanism in glioma remain unclear. Lin explored the role and mechanism of SCIN in gliomas. The results showed that SCIN mechanically affected cytoskeleton remodeling and inhibited the formation of lamellipodia RhoA/FAK signaling pathway. This study identifies the cancer-promoting role of SCIN and provides a potential therapeutic target for SCIN in glioma treatment.
胶质瘤是最常见的原发性颅内肿瘤之一，其特征为浸润性生长且预后不良。肌动蛋白细胞骨架重排是肿瘤细胞迁移中的一个重要事件。Scinderin（SCIN）是一种调节肌动蛋白细胞骨架的肌动蛋白切断和封端蛋白，参与某些癌细胞的增殖和迁移。然而，其在胶质瘤中的生物学作用和分子机制仍不清楚。林探讨了SCIN在胶质瘤中的作用和机制。结果表明，SCIN在机械上影响细胞骨架重塑，并抑制片足的形成 RhoA/FAK信号通路。本研究确定了SCIN的促癌作用，并为SCIN在胶质瘤治疗中提供了一个潜在的治疗靶点。
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