Engstrom Allison C, Alitin John Paul, Kapoor Arunima, Dutt Shubir, Lohman Trevor, Sible Isabel J, Marshall Anisa J, Shenasa Fatemah, Gaubert Aimée, Ferrer Farrah, Nguyen Amy, Bradford David Robert, Rodgers Kathleen, Sordo Lorena, Head Elizabeth, Shao Xingfeng, Wang Danny Jj, Nation Daniel A
Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
medRxiv. 2024 Jun 19:2024.06.18.24309109. doi: 10.1101/2024.06.18.24309109.
Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory impairment.
161 older adults free of dementia or major neurological/psychiatric disorders were recruited. Participants underwent clinical interviews, cognitive testing, venipuncture for Alzheimer's biomarkers, and brain MRI. Spontaneous CVR was quantified during 5 minutes of rest.
Whole brain CVR was negatively associated with age, but not MCI. Lower CVR in the parahippocampal gyrus (PHG) was found in participants with MCI and was linked to worse memory performance on memory tests. Results remained significant after adjusting for Alzheimer's biomarkers and vascular risk factors.
Spontaneous CVR deficits in the PHG are observed in older adults with MCI and memory impairment, indicating medial temporal microvascular dysfunction's role in cognitive decline.
轻度认知障碍（MCI）的老年人表现出脑血管反应性（CVR）缺陷，这表明CVR是血管对MCI影响的生物标志物。本研究调查了自发性CVR是否与MCI和记忆障碍有关。
招募了161名无痴呆或重大神经/精神疾病的老年人。参与者接受了临床访谈、认知测试、用于阿尔茨海默病生物标志物的静脉穿刺以及脑部MRI检查。在休息5分钟期间对自发性CVR进行量化。
全脑CVR与年龄呈负相关，但与MCI无关。在MCI参与者中发现海马旁回（PHG）的CVR较低，并且与记忆测试中较差的记忆表现相关。在调整阿尔茨海默病生物标志物和血管危险因素后，结果仍然显著。
在患有MCI和记忆障碍的老年人中观察到PHG的自发性CVR缺陷，表明内侧颞叶微血管功能障碍在认知衰退中的作用。
