Engstrom Allison C, Alitin John Paul M, Kapoor Arunima, Dutt Shubir, Lohman Trevor, Sible Isabel J, Marshall Anisa J, Shenasa Fatemah, Gaubert Aimée, Ferrer Farrah, Nguyen Amy, Bradford David Robert, Rodgers Kathleen, Sordo Lorena, Head Elizabeth, Shao Xingfeng, Wang Danny J J, Nation Daniel A
Department of Psychological Science, University of California, Irvine, Irvine, California, USA.
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Alzheimers Dement. 2025 Jan;21(1):e14396. doi: 10.1002/alz.14396. Epub 2024 Nov 18.
Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory impairment.
One hundred sixty-one older adults free of dementia or major neurological/psychiatric disorders were recruited. Participants underwent clinical interviews, cognitive testing, venipuncture for Alzheimer's disease (AD) biomarkers, and brain magnetic resonance imaging. Spontaneous CVR was quantified during 5 minutes of rest. Respiratory gases analyzed through nasal cannula to quantify end-tidal carbon dioxide (CO) levels were used to estimate CVR.
Whole brain CVR was negatively associated with age, but not MCI. Lower CVR in the parahippocampal gyrus (PHG) was found in participants with MCI and was linked to worse memory performance on memory tests. Results remained significant after adjusting for AD biomarkers and vascular risk factors.
Spontaneous CVR deficits in the PHG are observed in older adults with MCI and memory impairment, suggesting medial temporal microvascular dysfunction is observed in cognitive decline.
Aging is associated with decline in whole brain spontaneous cerebrovascular reactivity (CVR). Older adults with mild cognitive impairment exhibit deficits in spontaneous CVR in the parahippocampal gyrus (PHG). Memory impairment is correlated with reduced spontaneous CVR in the PHG.
患有轻度认知障碍（MCI）的老年人表现出脑血管反应性（CVR）缺陷，这表明CVR是血管对MCI影响的一个生物标志物。本研究调查了自发性CVR是否与MCI和记忆障碍有关。
招募了161名无痴呆或重大神经/精神疾病的老年人。参与者接受了临床访谈、认知测试、用于检测阿尔茨海默病（AD）生物标志物的静脉穿刺以及脑磁共振成像。在休息5分钟期间对自发性CVR进行量化。通过鼻导管分析呼吸气体以量化呼气末二氧化碳（CO）水平，用于估计CVR。
全脑CVR与年龄呈负相关，但与MCI无关。在患有MCI的参与者中发现海马旁回（PHG）的CVR较低，并且与记忆测试中较差的记忆表现相关。在调整AD生物标志物和血管危险因素后，结果仍然显著。
在患有MCI和记忆障碍的老年人中观察到PHG的自发性CVR缺陷，这表明在认知衰退中观察到内侧颞叶微血管功能障碍。
衰老与全脑自发性脑血管反应性（CVR）下降有关。患有轻度认知障碍的老年人在海马旁回（PHG）表现出自发性CVR缺陷。记忆障碍与PHG中自发性CVR降低相关。
