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浸软处理对白化雌性大鼠卵巢卵泡发育、血清雌二醇、子宫生长及血管形成的影响

Effect of maceration treatment on ovarian follicular development, serum oestradiol, uterine growth and vascularisation in female albino rats.

作者信息

Andriyanto Andriyanto, Putra Hamdika Yendri, Subangkit Mawar, Tarigan Elpita, Nugrahaning Widi Leliana, Irarang Yusa, Manalu Wasmen, Fadholly Amaq

机构信息

Division of Pharmacology and Toxicology, West Java, Indonesia.

eLRosa Laboratory, iRATco Group, Dramaga Bogor, 16680 West Java, Indonesia.

出版信息

J Vet Res. 2024 Apr 4;68(2):287-294. doi: 10.2478/jvetres-2024-0020. eCollection 2024 Jun.

DOI:10.2478/jvetres-2024-0020
PMID:38947163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11210355/
Abstract

INTRODUCTION

is a well-known medicinal plant with various health benefits. This study was designed to evaluate the administration of Indonesian maceration for its effect on promoting growth and development of the ovary and uterus before mating in female albino rats.

MATERIAL AND METHODS

A total of 15 female Sprague Dawley rats in their dioestrous phase were assigned into three different groups: the Control group (mineral water); the Cur-Low group (mineral water with 1% maceration) and the Cur-High group (mineral water with 5% maceration). The treatments were given for 20 days. Serum concentrations of follicle-stimulating hormone, oestradiol and progesterone were determined. After the sacrifice of the rats, ovary and uterine relative weight, uterine cornua diameter and length, uterine gland diameter (by histology), the number of primary, secondary, tertiary, and Graafian follicles, the number of corpora lutea and vascular endothelial growth factor (VEGF) expression in the ovary were measured. Uterine vascularisation was also evaluated.

RESULTS

Administration of maceration significantly improved the relative weights of the uterus and ovary; uterine cornua diameter, length and vascularisation; uterine gland diameter; and expression of VEGF in the ovary. It also increased the number of tertiary follicles and corpora lutea, albeit not significantly. Follicle-stimulating hormone serum concentrations were lower in the administered rats.

CONCLUSION

Oestradiol and progesterone levels rose with maceration treatment. The maceration improved the reproductive organs of unmated rats and had potential to optimise the uterine environment for supporting pregnancy in order to produce high-quality offspring.

摘要

引言

是一种具有多种健康益处的著名药用植物。本研究旨在评估印尼浸剂给药对雌性白化大鼠交配前卵巢和子宫生长发育的影响。

材料与方法

将15只处于动情间期的雌性斯普拉格-道利大鼠分为三组：对照组（饮用矿泉水）；低剂量姜黄浸剂组（饮用含1%姜黄浸剂的矿泉水）和高剂量姜黄浸剂组（饮用含5%姜黄浸剂的矿泉水）。给药20天。测定血清卵泡刺激素、雌二醇和孕酮浓度。大鼠处死后，测量卵巢和子宫相对重量、子宫角直径和长度、子宫腺直径（通过组织学）、初级、次级、三级和格拉夫卵泡数量、黄体数量以及卵巢中血管内皮生长因子（VEGF）表达。还评估了子宫血管生成情况。

结果

给予姜黄浸剂显著改善了子宫和卵巢的相对重量；子宫角直径、长度和血管生成；子宫腺直径；以及卵巢中VEGF的表达。它还增加了三级卵泡和黄体的数量，尽管不显著。给药大鼠血清卵泡刺激素浓度较低。

结论

浸剂处理后雌二醇和孕酮水平升高。浸剂改善了未交配大鼠的生殖器官，并有可能优化子宫环境以支持妊娠，从而产生高质量后代。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/6744e037e41f/j_jvetres-2024-0020_fig_007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/70ac6d4dff77/j_jvetres-2024-0020_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/06c781d2fb45/j_jvetres-2024-0020_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/7781270ad11c/j_jvetres-2024-0020_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/6083e8039076/j_jvetres-2024-0020_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/fe24bab0fe35/j_jvetres-2024-0020_fig_005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/f196a300466c/j_jvetres-2024-0020_fig_006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/6744e037e41f/j_jvetres-2024-0020_fig_007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/70ac6d4dff77/j_jvetres-2024-0020_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/06c781d2fb45/j_jvetres-2024-0020_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/7781270ad11c/j_jvetres-2024-0020_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/6083e8039076/j_jvetres-2024-0020_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/fe24bab0fe35/j_jvetres-2024-0020_fig_005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/f196a300466c/j_jvetres-2024-0020_fig_006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0864/11210355/6744e037e41f/j_jvetres-2024-0020_fig_007.jpg

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