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姜黄素:对其对人类健康影响的综述。

Curcumin: A Review of Its Effects on Human Health.

作者信息

Hewlings Susan J, Kalman Douglas S

机构信息

Department of Nutrition, Central Michigan University Mount Pleasant, MI, USA and Substantiation Sciences Weston, FL 33143, USA.

Health and Human Performance, Nova Southeastern University and Nutrition Research Division, QPS, Miami, FL 33143, USA.

出版信息

Foods. 2017 Oct 22;6(10):92. doi: 10.3390/foods6100092.

DOI:10.3390/foods6100092
PMID:29065496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5664031/
Abstract

Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Curcumin combined with enhancing agents provides multiple health benefits. The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits of curcumin.

摘要

姜黄,一种长期以来因其药用特性而闻名的香料,受到了医学/科学界和烹饪爱好者的关注,因为它是多酚类姜黄素的主要来源。它有助于管理氧化和炎症状况、代谢综合征、关节炎、焦虑症和高脂血症。它还可能有助于管理运动引起的炎症和肌肉酸痛,从而提高活跃人群的恢复能力和运动表现。此外,相对低剂量的这种复合物可以为未被诊断出健康问题的人带来健康益处。这些益处大多可归因于其抗氧化和抗炎作用。由于姜黄素的生物利用度差,单独摄入姜黄素不会带来相关的健康益处,这似乎主要是由于吸收不良、代谢迅速和排泄快速。有几种成分可以提高生物利用度。例如,胡椒碱是黑胡椒的主要活性成分,当与姜黄素复合时,已被证明可使生物利用度提高2000%。姜黄素与增强剂结合可带来多种健康益处。本综述的目的是简要概述关于姜黄素健康益处的大量研究。

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本文引用的文献

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Clin Sci (Lond). 2017 Jul 5;131(15):1781-1799. doi: 10.1042/CS20160935. Print 2017 Aug 1.
2
Curcumin and Piperine Supplementation and Recovery Following Exercise Induced Muscle Damage: A Randomized Controlled Trial.姜黄素与胡椒碱补充剂及运动诱导的肌肉损伤后的恢复:一项随机对照试验。
J Sports Sci Med. 2017 Mar 1;16(1):147-153. eCollection 2017 Mar.
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Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes.姜黄素和锯叶乳香调节顶级运动员的糖氧化状态和脂质氧化。
Nutrients. 2016 Nov 21;8(11):745. doi: 10.3390/nu8110745.
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Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.姜黄提取物和姜黄素缓解关节性关节炎症状的疗效:随机临床试验的系统评价和荟萃分析
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Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial.姜黄素对代谢综合征患者血清细胞因子浓度的影响:一项随机对照试验的事后分析。
Biomed Pharmacother. 2016 Aug;82:578-82. doi: 10.1016/j.biopha.2016.05.037. Epub 2016 Jun 6.
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Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin.口服生物可利用姜黄素后炎症和肌肉损伤生物标志物减少。
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Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?氧化应激与炎症之间的相互依存关系能否解释抗氧化剂悖论?
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Curcumin, an active component of turmeric (Curcuma longa), and its effects on health.姜黄中的一种活性成分——姜黄素及其对健康的影响。
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An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial.姜黄素对肥胖个体焦虑和抑郁影响的调查:一项随机对照试验。
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