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脊髓损伤中的电刺激与运动功能康复:一项系统综述。

Electrical Stimulation and Motor Function Rehabilitation in Spinal Cord Injury: A Systematic Review.

作者信息

Kanakis Asterios K, Benetos Ioannis S, Evangelopoulos Dimitrios Stergios, Vlamis John, Vasiliadis Elias S, Kotroni Aikaterini, Pneumaticos Spyros G

机构信息

Department of Physical Medicine and Rehabilitation, KAT Hospital, Athens, GRC.

3rd Department of Orthopaedic Surgery, National and Kapodistrian University of Athens (NKUA) KAT Hospital, Athens, GRC.

出版信息

Cureus. 2024 May 31;16(5):e61436. doi: 10.7759/cureus.61436. eCollection 2024 May.

DOI:10.7759/cureus.61436
PMID:38947571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11214755/
Abstract

Spinal cord injury (SCI) often leads to devastating motor impairments, significantly affecting the quality of life of affected individuals. Over the last decades, spinal cord electrical stimulation seems to have encouraging effects on the motor recovery of impacted patients. This review aimed to identify clinical trials focused on motor function recovery through the application of epidural electrical stimulation, transcutaneous electrical stimulation, and functional electrical stimulation. Several clinical trials met these criteria, focusing on the impact of the aforementioned interventions on walking, standing, swimming, trunk stability, and upper extremity functionality, particularly grasp. After a thorough PubMed online database research, 37 clinical trials were included in this review, with a total of 192 patients. Many of them appeared to have an improvement in function, either clinically assessed or recorded through electromyography. This review outlines the various ways electrical stimulation techniques can aid in the motor recovery of SCI patients. It stresses the ongoing need for medical research to refine these techniques and ultimately enhance rehabilitation results in clinical settings.

摘要

脊髓损伤(SCI)常常导致严重的运动功能障碍,极大地影响患者的生活质量。在过去几十年中,脊髓电刺激似乎对受影响患者的运动恢复具有令人鼓舞的效果。本综述旨在确定聚焦于通过应用硬膜外电刺激、经皮电刺激和功能性电刺激来恢复运动功能的临床试验。有几项临床试验符合这些标准,重点关注上述干预措施对行走、站立、游泳、躯干稳定性和上肢功能(特别是抓握功能)的影响。在对PubMed在线数据库进行全面检索后,本综述纳入了37项临床试验,共有192名患者。其中许多患者在功能上似乎有改善,无论是通过临床评估还是通过肌电图记录。本综述概述了电刺激技术有助于脊髓损伤患者运动恢复的各种方式。它强调了医学研究持续需要改进这些技术,并最终在临床环境中提高康复效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1910/11214755/41b4ba5e9283/cureus-0016-00000061436-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1910/11214755/41b4ba5e9283/cureus-0016-00000061436-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1910/11214755/41b4ba5e9283/cureus-0016-00000061436-i01.jpg

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本文引用的文献

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A case study of percutaneous epidural stimulation to enable motor control in two men after spinal cord injury.经皮硬膜外刺激治疗脊髓损伤后两名男性运动控制的病例研究。
Nat Commun. 2023 Apr 12;14(1):2064. doi: 10.1038/s41467-023-37845-7.
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Activating effective functional hand movements in individuals with complete tetraplegia through neural stimulation.通过神经刺激使四肢完全瘫痪的个体激活有效的功能性手部运动。
Sci Rep. 2022 Oct 6;12(1):16189. doi: 10.1038/s41598-022-19906-x.
3
Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury.
硬膜外电极刺激在3例AIS D级不完全性脊髓损伤患者中的作用
Biomedicines. 2025 Jan 10;13(1):155. doi: 10.3390/biomedicines13010155.
经皮电刺激改善严重脊髓损伤患者手部功能所需的握持力极小。
Sci Rep. 2022 May 11;12(1):7733. doi: 10.1038/s41598-022-11306-5.
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Neuroplasticity of spinal cord injury and repair.脊髓损伤与修复的神经可塑性。
Handb Clin Neurol. 2022;184:317-330. doi: 10.1016/B978-0-12-819410-2.00017-5.
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Transcutaneous Spinal Cord Stimulation Restores Hand and Arm Function After Spinal Cord Injury.经皮脊髓电刺激可恢复脊髓损伤后的手和手臂功能。
IEEE Trans Neural Syst Rehabil Eng. 2021;29:310-319. doi: 10.1109/TNSRE.2021.3049133. Epub 2021 Mar 2.
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Why brain-controlled neuroprosthetics matter: mechanisms underlying electrical stimulation of muscles and nerves in rehabilitation.为什么脑控神经假体很重要:康复中肌肉和神经电刺激的机制。
Biomed Eng Online. 2020 Nov 4;19(1):81. doi: 10.1186/s12938-020-00824-w.
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Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms.脊髓损伤:病理生理学、多分子相互作用和潜在的恢复机制。
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Epidural Electrical Stimulation: A Review of Plasticity Mechanisms That Are Hypothesized to Underlie Enhanced Recovery From Spinal Cord Injury With Stimulation.硬膜外电刺激:对被假定为脊髓损伤刺激后恢复增强基础的可塑性机制的综述。
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