CAMIN, INRIA, University of Montpellier, Montpellier, France.
NEURINNOV, Montpellier, France.
Sci Rep. 2022 Oct 6;12(1):16189. doi: 10.1038/s41598-022-19906-x.
Individuals with complete cervical spinal cord injury suffer from a permanent paralysis of upper limbs which prevents them from achieving most of the activities of daily living. We developed a neuroprosthetic solution to restore hand motor function. Electrical stimulation of the radial and median nerves by means of two epineural electrodes enabled functional movements of paralyzed hands. We demonstrated in two participants with complete tetraplegia that selective stimulation of nerve fascicles by means of optimized spreading of the current over the active contacts of the multicontact epineural electrodes induced functional and powerful grasping movements which remained stable over the 28 days of implantation. We also showed that participants were able to trigger the activation of movements of their paralyzed limb using an intuitive interface controlled by voluntary actions and that they were able to perform useful functional movements such as holding a can and drinking through a straw.
完全性颈髓损伤的个体上肢会永久性瘫痪，导致他们无法完成大部分日常生活活动。我们开发了一种神经假体解决方案来恢复手部运动功能。通过两根神经外膜电极对桡神经和正中神经进行电刺激，使瘫痪的手能够进行功能性运动。我们在两名完全性四肢瘫痪的参与者中证明，通过优化电流在多触点神经外膜电极的活动触点上的扩散，对神经束进行选择性刺激，可以诱导出功能性且有力的抓握运动，并且这种刺激在 28 天的植入过程中保持稳定。我们还表明，参与者能够使用由自主行为控制的直观界面触发瘫痪肢体运动的激活，并且他们能够进行有用的功能性运动，例如握持罐子和通过吸管喝水。
