Nimodia Devyansh, Parihar Pratapsingh, Gaur Shubhi, Desale Prasad, Mishra Komal
Radiodiagnosis, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 May 30;16(5):e61360. doi: 10.7759/cureus.61360. eCollection 2024 May.
Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are rare neurological disorders associated with rapid correction of hyponatremia, particularly in individuals with chronic alcohol use. We present the case of a 52-year-old male with a history of chronic alcoholism who developed CPM and EPM following correction of severe hyponatremia. The patient presented with dysarthria, hemiparesis, and altered mental status, which progressed rapidly to pseudobulbar features and spastic quadriparesis. Neuroimaging revealed characteristic findings of CPM and EPM. Treatment with intravenous dexamethasone, intravenous immunoglobulin (IVIG), and methylprednisolone led to gradual neurological improvement. The patient showed significant recovery after two months, highlighting the importance of early recognition and cautious management of electrolyte disturbances in high-risk individuals to prevent devastating neurological complications.
中央桥脑髓鞘溶解症(CPM)和脑桥外髓鞘溶解症(EPM)是罕见的神经系统疾病,与低钠血症的快速纠正有关,尤其是在慢性酒精使用的个体中。我们报告一例52岁有慢性酒精中毒病史的男性,在严重低钠血症纠正后发生了CPM和EPM。患者表现为构音障碍、偏瘫和精神状态改变,迅速进展为假性球麻痹特征和痉挛性四肢瘫。神经影像学显示了CPM和EPM的特征性表现。静脉注射地塞米松、静脉注射免疫球蛋白(IVIG)和甲基强的松龙治疗导致神经功能逐渐改善。两个月后患者有显著恢复,突出了早期识别和谨慎处理高危个体电解质紊乱以预防毁灭性神经并发症的重要性。