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本文引用的文献

1
Treatment of Tardive Dyskinesia: A General Overview with Focus on the Vesicular Monoamine Transporter 2 Inhibitors.迟发性运动障碍的治疗：概述及重点关注囊泡单胺转运体 2 抑制剂。
Drugs. 2018 Apr;78(5):525-541. doi: 10.1007/s40265-018-0874-x.
2
Mechanism of action of vesicular monoamine transporter 2 (VMAT2) inhibitors in tardive dyskinesia: reducing dopamine leads to less "go" and more "stop" from the motor striatum for robust therapeutic effects.囊泡单胺转运体 2（VMAT2）抑制剂在迟发性运动障碍中的作用机制：减少多巴胺可使运动纹状体减少“启动”，增加“停止”，从而产生强大的治疗效果。
CNS Spectr. 2018 Feb;23(1):1-6. doi: 10.1017/S1092852917000621. Epub 2017 Dec 18.
3
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission.血清素对多巴胺神经传递调节的药理学机制。
Pharmacol Ther. 2007 Feb;113(2):296-320. doi: 10.1016/j.pharmthera.2006.08.004. Epub 2006 Oct 17.
4
Movement disorders associated with the serotonin selective reuptake inhibitors.与血清素选择性再摄取抑制剂相关的运动障碍。
J Clin Psychiatry. 1996 Oct;57(10):449-54. doi: 10.4088/jcp.v57n1002.

一种意外现象：一例西酞普兰诱发的运动障碍病例。

An Unexpected Phenomenon: A Case of Citalopram-Induced Dyskinesia.

作者信息

Jean Fabienne J, Poulose Michael

机构信息

Neurology, Touro College of Osteopathic Medicine, New York City, USA.

Emergency Department, St. Joseph Medical Center, Bethpage, USA.

出版信息

Cureus. 2024 May 30;16(5):e61364. doi: 10.7759/cureus.61364. eCollection 2024 May.

DOI:10.7759/cureus.61364
PMID:38947732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11214379/
Abstract

Dyskinetic movements are characterized as hyperkinetic, repetitive movements of the extremities, facial, and oral musculature, most associated with prolonged dopamine D2 receptor blockade. In rare instances, dyskinetic movements can be brought on by selective serotonin reuptake inhibitor (SSRI) usage via an indirect D2 blockade mechanism, mimicking the D2 blockade observed with dopamine receptor blocking agents (DRBAs), such as in first-generation antipsychotics. This mimicked D2 blockade by SSRIs is said to be due to increased tonic inhibition by serotonin on dopaminergic neurons in the dopaminergic pathways of the brain, specifically the nigrostriatal pathway. In this case report, we look at a patient with a history of cerebral palsy who developed acute dyskinetic movements after short-term citalopram usage. The objective is to bring attention to the possible extrapyramidal side effects (EPS) of SSRI usage.

摘要

运动障碍性运动的特征是肢体、面部和口腔肌肉组织出现运动亢进、重复性运动，大多与长期多巴胺D2受体阻断有关。在罕见情况下，运动障碍性运动可由选择性5-羟色胺再摄取抑制剂（SSRI）通过间接D2阻断机制引发，模拟多巴胺受体阻断剂（DRBA）（如第一代抗精神病药物）所观察到的D2阻断情况。据说SSRI这种模拟的D2阻断是由于5-羟色胺对大脑多巴胺能通路（特别是黑质纹状体通路）中多巴胺能神经元的紧张性抑制增加所致。在本病例报告中，我们观察了一名有脑瘫病史的患者，其在短期使用西酞普兰后出现急性运动障碍性运动。目的是提醒人们注意使用SSRI可能出现的锥体外系副作用（EPS）。