Ozalp Elvan, Soygur Haldun, Cankurtaran Eylem S, Turhan Levent, Cekic Tuğba, Akarsu Eyüp S, Palaoglu Ozden, Ayhan Ismail H
Ankara Oncology Training and Research Hospital, Psychiatry Clinic, Kolej, Ankara, Turkey.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1337-9. doi: 10.1016/j.pnpbp.2006.03.002. Epub 2006 Apr 4.
It is not scarce that patients experience various extrapyramidal symptoms (EPS) during antidepressant drug therapy. Thus, choice of an antidepressant drug in case of extrapyramidal side effects, at present, is a dilemma. Escitalopram, which is a recently marketed selective serotonin reuptake inhibitors (SSRI), has no such reputation. There is just one case reported for tianeptine that induced abnormal involuntary movements/extrapyramidal side effects. We would like to present a case that was successfully managed with bupropion which had developed EPS during 2 different SSRI (sertraline and escitalopram) and tianeptine therapy.
患者在抗抑郁药物治疗期间出现各种锥体外系症状(EPS)的情况并不少见。因此,目前在出现锥体外系副作用时选择抗抑郁药物是一个两难的问题。艾司西酞普兰是最近上市的选择性5-羟色胺再摄取抑制剂(SSRI),没有此类不良声誉。仅报道过1例噻奈普汀引起异常不自主运动/锥体外系副作用的病例。我们想介绍1例在两种不同的SSRI(舍曲林和艾司西酞普兰)及噻奈普汀治疗期间出现EPS后成功使用安非他酮治疗的病例。