Fan Ranran, Cheng Yi, Wang Rongrong, Zhang Ting, Zhang Hui, Li Jianchun, Song Shenghan, Zheng Aiping
School of Pharmacy, Bengbu Medical College, Anhui 233030, China.
College of Pharmacy, Yanbian University, Jilin 133002, China.
Polymers (Basel). 2022 Jun 12;14(12):2379. doi: 10.3390/polym14122379.
Thermosensitive hydrogels, having unique sol-gel transition properties, have recently received special research attention. These hydrogels exhibit a phase transition near body temperature. This feature is the key to their applications in human medicine. In addition, hydrogels can quickly gel at the application site with simple temperature stimulation and without additional organic solvents, cross-linking agents, or external equipment, and the loaded drugs can be retained locally to improve the local drug concentration and avoid unexpected toxicity or side effects caused by systemic administration. All of these features have led to thermosensitive hydrogels being some of the most promising and practical drug delivery systems. In this paper, we review thermosensitive hydrogel materials with biomedical application potential, including natural and synthetic materials. We describe their structural characteristics and gelation mechanism and briefly summarize the mechanism of drug release from thermosensitive hydrogels. Our focus in this review was to summarize the application of thermosensitive hydrogels in disease treatment, including the postoperative recurrence of tumors, the delivery of vaccines, the prevention of postoperative adhesions, the treatment of nervous system diseases via nasal brain targeting, wound healing, and osteoarthritis treatment.
具有独特溶胶-凝胶转变特性的热敏水凝胶最近受到了特别的研究关注。这些水凝胶在体温附近呈现相变。这一特性是它们在人类医学中应用的关键。此外，水凝胶在简单的温度刺激下，无需额外的有机溶剂、交联剂或外部设备，就能在应用部位快速凝胶化，并且负载的药物可以局部保留，以提高局部药物浓度，避免全身给药引起的意外毒性或副作用。所有这些特性使得热敏水凝胶成为一些最有前景和实用性的药物递送系统。在本文中，我们综述了具有生物医学应用潜力的热敏水凝胶材料，包括天然材料和合成材料。我们描述了它们的结构特征和凝胶化机制，并简要总结了药物从热敏水凝胶中释放的机制。我们在这篇综述中的重点是总结热敏水凝胶在疾病治疗中的应用，包括肿瘤术后复发、疫苗递送、预防术后粘连、通过鼻脑靶向治疗神经系统疾病、伤口愈合和骨关节炎治疗。
