Kaur Brahmleen, Kobayashi Yoshifumi, Cugini Carla, Shimizu Emi
Department of Oral and Maxillofacial Surgery, Rutgers School of Dental Medicine, Newark, NJ, United States.
Department of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ, United States.
Front Dent Med. 2021;2. doi: 10.3389/fdmed.2021.718445. Epub 2021 Dec 19.
For assessing the adequacy of vital pulp therapy for an inflamed pulp, the use of non-invasive diagnostic tools is necessary to avoid further damage to the teeth. Detection of biomarkers that are indicative of the inflammatory status in pulp can be a promising tool for this purpose. These biomarkers need to be reliably correlated with pulpal inflammation and to be easily detected without pulp exposure. This mini-review article aims to review biomarkers that are present in gingival crevicular fluid (GCF) in inflamed pulp conditions. Several studies have reported the availability of various biomarkers including cytokines, proteases, elastase, neuropeptides, and growth factors. Non-invasive pulpal diagnostic methods will be useful as well to determine reversibility, irreversibility, or necrosis of inflamed pulp. These types of molecular diagnoses analyzing the proteome have revolutionized the medical field, and are one of the most promising empirical methodologies that a clinician can utilize for the proactive identification of pulpal disease.
为评估对炎症牙髓进行活髓治疗的充分性，必须使用非侵入性诊断工具以避免对牙齿造成进一步损伤。检测指示牙髓炎症状态的生物标志物可能是实现这一目的的一种有前景的工具。这些生物标志物需要与牙髓炎症可靠相关，并且在不暴露牙髓的情况下易于检测。这篇综述文章旨在回顾在炎症牙髓情况下龈沟液（GCF）中存在的生物标志物。多项研究报告了包括细胞因子、蛋白酶、弹性蛋白酶、神经肽和生长因子在内的各种生物标志物的可用性。非侵入性牙髓诊断方法对于确定炎症牙髓的可逆性、不可逆性或坏死也将是有用的。这些分析蛋白质组的分子诊断类型已经彻底改变了医学领域，并且是临床医生可用于主动识别牙髓疾病的最有前景的经验方法之一。
