Zwiri Abdalwhab, Al-Hatamleh Mohammad A I, W Ahmad Wan Muhamad Amir, Ahmed Asif Jawaad, Khoo Suan Phaik, Husein Adam, Ab-Ghani Zuryati, Kassim Nur Karyatee
School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Department of Immunology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Diagnostics (Basel). 2020 May 15;10(5):303. doi: 10.3390/diagnostics10050303.
Numerous studies have been conducted in the previous years with an objective to determine the ideal biomarker or set of biomarkers in temporomandibular disorders (TMDs). It was recorded that tumour necrosis factor (TNF), interleukin 8 (IL-8), IL-6, and IL-1 were the most common biomarkers of TMDs. As of recently, although the research on TMDs biomarkers still aims to find more diagnostic agents, no recent study employs the biomarker as a targeting point of pharmacotherapy to suppress the inflammatory responses. This article represents an explicit review on the biomarkers of TMDs that have been discovered so far and provides possible future directions towards further research on these biomarkers. The potential implementation of the interactions of TNF with its receptor 2 (TNFR2) in the inflammatory process has been interpreted, and thus, this review presents a new hypothesis towards suppression of the inflammatory response using TNFR2-agonist. Subsequently, this hypothesis could be explored as a potential pain elimination approach in patients with TMDs.
在过去几年中进行了大量研究，目的是确定颞下颌关节紊乱病（TMDs）的理想生物标志物或生物标志物组合。据记录，肿瘤坏死因子（TNF）、白细胞介素8（IL-8）、IL-6和IL-1是TMDs最常见的生物标志物。截至最近，尽管对TMDs生物标志物的研究仍旨在寻找更多诊断试剂，但最近没有研究将生物标志物作为药物治疗的靶点来抑制炎症反应。本文对迄今为止发现的TMDs生物标志物进行了明确综述，并为这些生物标志物的进一步研究提供了可能的未来方向。已对TNF与其受体2（TNFR2）在炎症过程中的相互作用的潜在应用进行了解释，因此，本综述提出了一种使用TNFR2激动剂抑制炎症反应的新假设。随后，这一假设可作为TMDs患者潜在的疼痛消除方法进行探索。
