Antifungal Activity of 3-Hydrazinoquinoxaline-2-Thiol, a Novel Quinoxaline Derivative against Candida Species.

ranks as among the most frequently encountered fungal infections that associated with high morbidity and mortality. Quinoxaline derivatives are a group of small molecules that showed a promising antimicrobial activity. This study aimed to investigate the fungicidal effects of 3-hydrazinoquinoxaline-2-thiol against in comparison with Amphotericin B as a reference. Also, we aim to assess the efficacy of 3-hydrazinoquinoxaline-2-thiol using mice oral candidiasis model. Fifty-six isolates were subjected to susceptibility testing by broth microdilution method for 3-hydrazinoquinoxaline-2-thiol and Amphotericin B. Therefore, Minimal inhibitory concentrations (MIC) were assessed and compared. The oral candidiasis mice model was used to evaluate the activity of 3-hydrazinoquinoxaline-2-thiol . Microbiological evaluation of progression and ELISA were used in this study. 3-hydrazinoquinoxaline-2-thiol was more effective than Amphotericin B against most clinical isolates of . Higher effectiveness was seen against and isolates. However, the efficiency against isolates varies. 3-hydrazinoquinoxaline-2-thiol was also effective against and . 3-hydrazinoquinoxaline-2-thiol showed a good efficacy in mice model against cells ATCC 10231. 3-hydrazinoquinoxaline-2-thiol has shown promising antifungal and anti-inflammatory activity against different species. More tests and experiments are needed.