Kim Hye-Yoom, Shin Sarah, Yoon Jung-Joo, Ahn You-Mee, Song Ji-Hye, Lee Da-Som, Park Ji-Yeun, Lee Ho-Sub, Jung Jeeyoun
Hanbang Cardio-renal Research Center & Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, South Korea.
KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.
Integr Med Res. 2024 Jun;13(2):101041. doi: 10.1016/j.imr.2024.101041. Epub 2024 Mar 27.
Investigating the effects of electroacupuncture (EA) treatment on cardiovascular function and aortic lipid profiles in spontaneously hypertensive rats (SHR) constitutes the foundational focus of this study. The overarching goal is to comprehensively elucidate the alterations brought about by EA treatment and to assess its potential as an alternative therapy for hypertension.
Consecutive EA treatments were administered to SHR, and the effects on systolic blood pressure, cardiac function, and hypertension-related neuronal signals were assessed. Aortic lipid profiles in vehicle-treated SHR and EA-treated SHR groups were analyzed using mass spectrometry-based lipid profiling. Additionally, the expression of Cers2 and GNPAT, enzymes involved in the synthesis of specific aortic lipids, was examined.
The study demonstrated that consecutive EA treatments restored systolic blood pressure, improved cardiovascular function, and normalized hypertension-related neuronal signals in SHR. Analysis of the aortic lipid profiles revealed distinct differences between the vehicle-treated SHR group and the EA-treated SHR group. Specifically, EA treatment significantly altered the levels of aortic sphingomyelin and phospholipids, including very long-chain fatty acyl-ceramides and ether phosphatidylcholines. These changes in aortic lipid profiles correlated significantly with systolic blood pressure and cardiac function indicators. Furthermore, EA treatment significantly altered the expression of Cers2 and GNPAT.
The findings suggest that EA may influence cardiovascular functions and aortic lipid profiles in SHR.
研究电针（EA）治疗对自发性高血压大鼠（SHR）心血管功能和主动脉脂质谱的影响是本研究的基础重点。总体目标是全面阐明EA治疗所带来的变化，并评估其作为高血压替代疗法的潜力。
对SHR进行连续的EA治疗，并评估其对收缩压、心脏功能和高血压相关神经信号的影响。使用基于质谱的脂质谱分析方法分析未接受治疗的SHR组和接受EA治疗的SHR组的主动脉脂质谱。此外，检测参与特定主动脉脂质合成的酶Cers2和GNPAT的表达。
研究表明，连续的EA治疗可恢复SHR的收缩压，改善心血管功能，并使高血压相关神经信号正常化。主动脉脂质谱分析显示，未接受治疗的SHR组和接受EA治疗的SHR组之间存在明显差异。具体而言，EA治疗显著改变了主动脉鞘磷脂和磷脂的水平，包括极长链脂肪酰神经酰胺和醚磷脂酰胆碱。主动脉脂质谱的这些变化与收缩压和心脏功能指标显著相关。此外，EA治疗显著改变了Cers2和GNPAT的表达。
研究结果表明，EA可能会影响SHR的心血管功能和主动脉脂质谱。
