Li Juan, Sun Mingsheng, Ye Jing, Li Yuxi, Jin Rongjiang, Zheng Hui, Liang Fanrong
College of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Int J Hypertens. 2019 Mar 7;2019:8676490. doi: 10.1155/2019/8676490. eCollection 2019.
Essential hypertension has a high incidence worldwide, and patients with essential hypertension endure a lifetime of medication, leading to a heavy economic burden on the patient's family and causing serious impacts on the patient's quality of life. Much evidence has demonstrated that acupuncture as an adjunctive therapy can lower blood pressure in patients with hypertension, but the mechanism of its action is unclear. This article reviews the research from 2000 to 2018 regarding the mechanism of acupuncture for hypertension, and we summarize the current knowledge about using acupuncture for hypertension. We found that the mechanism whereby acupuncture lowers blood pressure is related to the regulation of renin-angiotensin-aldosterone system, vascular endothelium, oxidative stress, neuroendocrine system, and so on. Besides, there may be cross-talk between multiple systems and multiple targets. We also investigate the influence factors of acupuncture for hypertension. These results may provide evidence and research ideas for the treatment of hypertension via acupuncture.
原发性高血压在全球范围内发病率很高，原发性高血压患者需终身服药，给患者家庭带来沉重经济负担，并对患者生活质量造成严重影响。大量证据表明，针刺作为一种辅助疗法可降低高血压患者的血压，但其作用机制尚不清楚。本文回顾了2000年至2018年关于针刺治疗高血压机制的研究，并总结了目前针刺治疗高血压的相关知识。我们发现，针刺降低血压的机制与肾素-血管紧张素-醛固酮系统、血管内皮、氧化应激、神经内分泌系统等的调节有关。此外，多个系统和多个靶点之间可能存在相互作用。我们还研究了针刺治疗高血压的影响因素。这些结果可为针刺治疗高血压提供证据和研究思路。
